Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 29552..30117 Replicon plasmid pLiLS1
Accession NZ_CP039260
Organism Leptospira interrogans strain FMAS_KW1

Toxin (Protein)


Gene name mazE Uniprot ID A0A0C5XAD8
Locus tag E4412_RS20360 Protein ID WP_000237066.1
Coordinates 29552..29875 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID A0A0F6H5X2
Locus tag E4412_RS20365 Protein ID WP_000648189.1
Coordinates 29869..30117 (-) Length 83 a.a.

Genomic Context

E4412_RS20375E4412_RS21190E4412_RS20325E4412_RS20330E4412_RS20335E4412_RS20340E4412_RS20345E4412_RS20350E4412_RS20355E4412_RS20360E4412_RS20365E4412_RS20370E4412_RS20380E4412_RS20385
Location: 31252..32145 (894 bp)
Type: Others
Protein ID: WP_000366212.1
Location: 34144..34374 (231 bp)
Type: Others
Protein ID: WP_174978842.1
Location: 24910..25356 (447 bp)
Type: Others
Protein ID: WP_017857748.1
Location: 25359..25658 (300 bp)
Type: Others
Protein ID: WP_000835631.1
Location: 26074..27384 (1311 bp)
Type: Others
Protein ID: WP_174978845.1
Location: 27728..28069 (342 bp)
Type: Others
Protein ID: WP_137108924.1
Location: 28063..28299 (237 bp)
Type: Others
Protein ID: WP_000443825.1
Location: 28645..29067 (423 bp)
Type: Others
Protein ID: WP_000402980.1
Location: 29116..29328 (213 bp)
Type: Others
Protein ID: WP_000447737.1
Location: 29552..29875 (324 bp)
Type: Toxin
Protein ID: WP_000237066.1
Location: 29869..30117 (249 bp)
Type: Antitoxin
Protein ID: WP_000648189.1
Location: 30332..31141 (810 bp)
Type: Others
Protein ID: Protein_38
Location: 32162..32371 (210 bp)
Type: Others
Protein ID: WP_137108925.1
Location: 32799..33719 (921 bp)
Type: Others
Protein ID: WP_137108926.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
E4412_RS2032524910..25356-447WP_017857748.1PIN domain-containing protein-
E4412_RS2033025359..25658-300WP_000835631.1type II toxin-antitoxin system Phd/YefM family antitoxin-
E4412_RS2033526074..27384-1311WP_174978845.1IS5 family transposase-
E4412_RS2034027728..28069-342WP_137108924.1endoribonuclease MazF-
E4412_RS2034528063..28299-237WP_000443825.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
E4412_RS2035028645..29067-423WP_000402980.1hypothetical protein-
E4412_RS2035529116..29328-213WP_000447737.1hypothetical protein-
E4412_RS2036029552..29875-324WP_000237066.1type II toxin-antitoxin system PemK/MazF family toxinToxin
E4412_RS2036529869..30117-249WP_000648189.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
E4412_RS2037030332..31141-810Protein_38IS4 family transposase-
E4412_RS2037531252..32145+894WP_000366212.1IS982 family transposase-
E4412_RS2038032162..32371-210WP_137108925.1BrnT family toxin-
E4412_RS2038532799..33719-921WP_137108926.1DUF2971 domain-containing protein-
E4412_RS2119034144..34374+231WP_174978842.1AraC family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..7820178201


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-105)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12168.59 Da        Isoelectric Point: 10.5161

>T123710 WP_000237066.1 NZ_CP039260:c29875-29552 [Leptospira interrogans]
MVISQYEVYLINLDPTVGHEIKKSRPCAIISPNEMNKTIGTIIIAPMTTKSRSYPTRVELTFQGKKGWIVLDQIRAVDKT
RLVKKLGKIDPKTVNKMKLVIKEMLVD

Download         Length: 324 bp

>T123710 NZ_CP039260:c29875-29552 [Leptospira interrogans]
ATGGTGATTTCTCAATACGAAGTATATCTAATAAATTTAGATCCAACGGTTGGACATGAGATAAAAAAATCAAGACCTTG
TGCAATAATCTCACCCAATGAAATGAATAAAACGATTGGAACAATTATTATTGCACCAATGACTACAAAATCTCGATCGT
ATCCGACAAGAGTTGAATTAACCTTTCAAGGAAAGAAGGGTTGGATTGTGTTAGATCAGATTCGAGCTGTCGATAAAACA
CGTCTGGTAAAGAAGTTAGGAAAAATAGATCCCAAAACAGTTAATAAAATGAAACTGGTAATAAAGGAAATGTTGGTTGA
TTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9507.04 Da        Isoelectric Point: 5.1749

>AT123710 WP_000648189.1 NZ_CP039260:c30117-29869 [Leptospira interrogans]
MKASVVKIGNSKGIRIPKAVLEECHIEEEVDLLIDNNKLIIVPLKSKPREGWEKQFKTMSSNKDDKLFIPDSIDLLDKDW
EW

Download         Length: 249 bp

>AT123710 NZ_CP039260:c30117-29869 [Leptospira interrogans]
ATGAAGGCTTCAGTCGTAAAAATAGGCAATTCCAAAGGTATTCGAATTCCCAAGGCAGTCTTAGAAGAATGTCATATTGA
AGAAGAAGTAGATTTACTAATCGATAATAACAAATTAATTATTGTACCTCTAAAATCGAAACCAAGAGAAGGGTGGGAAA
AACAATTTAAAACAATGTCATCTAATAAAGATGATAAATTATTTATTCCTGATTCAATAGATTTATTAGACAAGGATTGG
GAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0C5XAD8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F6H5X2

References