Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 1448938..1449514 Replicon chromosome
Accession NZ_CP039256
Organism Leptospira interrogans strain FMAS_KW2

Toxin (Protein)


Gene name chpK Uniprot ID Q93MT8
Locus tag E4413_RS06255 Protein ID WP_000617906.1
Coordinates 1449173..1449514 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID Q93MT9
Locus tag E4413_RS06250 Protein ID WP_000844758.1
Coordinates 1448938..1449186 (+) Length 83 a.a.

Genomic Context

E4413_RS06235E4413_RS06245E4413_RS06250E4413_RS06255E4413_RS06270E4413_RS06275E4413_RS20585E4413_RS06260E4413_RS06265
Location: 1444590..1446572 (1983 bp)
Type: Others
Protein ID: WP_137170961.1
Location: 1447825..1448121 (297 bp)
Type: Others
Protein ID: WP_000477061.1
Location: 1448938..1449186 (249 bp)
Type: Antitoxin
Protein ID: WP_000844758.1
Location: 1449173..1449514 (342 bp)
Type: Toxin
Protein ID: WP_000617906.1
Location: 1453390..1453857 (468 bp)
Type: Others
Protein ID: WP_000060053.1
Location: 1453854..1454258 (405 bp)
Type: Others
Protein ID: WP_001974506.1
Location: 1447213..1447671 (459 bp)
Type: Others
Protein ID: Protein_1149
Location: 1450539..1451531 (993 bp)
Type: Others
Protein ID: WP_137108480.1
Location: 1451671..1452606 (936 bp)
Type: Others
Protein ID: WP_000004530.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
E4413_RS062351444590..1446572+1983WP_137170961.1HD family phosphohydrolase-
E4413_RS205851447213..1447671-459Protein_1149hypothetical protein-
E4413_RS062451447825..1448121+297WP_000477061.1helix-turn-helix domain-containing protein-
E4413_RS062501448938..1449186+249WP_000844758.1ribbon-helix-helix domain-containing proteinAntitoxin
E4413_RS062551449173..1449514+342WP_000617906.1type II toxin-antitoxin system PemK/MazF family toxinToxin
E4413_RS062601450539..1451531-993WP_137108480.1CoA ester lyase-
E4413_RS062651451671..1452606-936WP_000004530.1ornithine carbamoyltransferase-
E4413_RS062701453390..1453857+468WP_000060053.1hypothetical protein-
E4413_RS062751453854..1454258+405WP_001974506.1pyridoxamine 5'-phosphate oxidase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12372.25 Da        Isoelectric Point: 6.3272

>T123707 WP_000617906.1 NZ_CP039256:1449173-1449514 [Leptospira interrogans]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVFISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGEVEIGLKLVTGLD

Download         Length: 342 bp

>T123707 NZ_CP039256:1449173-1449514 [Leptospira interrogans]
ATGATTCGTGGTGAAATTTGGTGGGTAGACTTGGGAATTCCATTTGGAAGTGAGCCTGGATTTAAACGTCCAGTTCTTAT
AATTCAAGATGACTCTTTTAATCAAAGTAATATTAATACAATAGTTTCGATTGCAATTACATCGAATTTAAATCTATCTG
AAGCACCAGGTAATGTTTTCATTAGTAAAAAAGATTCGAGTTTATCAAAGGACTCGGTCATAAATGTTTCTCAAATTGTG
ACTTTAGATAAAGAAAGATTTCTTAACAAAGCGGGTAAACTTAAATCAAATAAATTAGGTGAAGTTGAAATTGGGCTTAA
GTTGGTTACAGGCTTAGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9380.77 Da        Isoelectric Point: 10.3815

>AT123707 WP_000844758.1 NZ_CP039256:1448938-1449186 [Leptospira interrogans]
MKTAISIPDELFRAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETRNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT123707 NZ_CP039256:1448938-1449186 [Leptospira interrogans]
ATGAAGACGGCGATTTCAATTCCTGATGAGTTATTTAGGGCTGCCGAGAAAATAGCTAAAAAACTTGGGATTCCTCGAAG
CCAGTTATTTGCAAAAGCATTAGAAGAATTTATCCAATCTCATAGTAAAGAATCTGTAACTGAGAAATTAAATAAAATCT
ACAGTAATAAATCCAAAGAAACTAGAAATAATATTACTGACTTATCCGTAGAATCGCTTCGTAAGAGTTTAAAAAATGAT
TCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0M4MS74

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F6HD92

References