Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 880286..881523 Replicon chromosome
Accession NZ_CP039250
Organism Sphingopyxis sp. PAMC25046

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E5675_RS04090 Protein ID WP_136173458.1
Coordinates 880286..880897 (-) Length 204 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E5675_RS04095 Protein ID WP_136173459.1
Coordinates 880978..881523 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5675_RS04060 875657..876907 + 1251 WP_136173452.1 threonine ammonia-lyase -
E5675_RS04065 876904..877296 + 393 WP_136173453.1 acyl-CoA thioesterase -
E5675_RS04070 877300..877887 + 588 WP_136173454.1 hypothetical protein -
E5675_RS04075 877892..878371 + 480 WP_136173455.1 GNAT family N-acetyltransferase -
E5675_RS04080 878373..878852 - 480 WP_136173456.1 MarR family winged helix-turn-helix transcriptional regulator -
E5675_RS04085 878836..880155 - 1320 WP_136173457.1 S41 family peptidase -
E5675_RS04090 880286..880897 - 612 WP_136173458.1 HD domain-containing protein Toxin
E5675_RS04095 880978..881523 - 546 WP_136173459.1 helix-turn-helix domain-containing protein Antitoxin
E5675_RS04100 881580..882275 - 696 WP_136173460.1 class I SAM-dependent methyltransferase -
E5675_RS04105 882268..882732 - 465 WP_136173461.1 Rrf2 family transcriptional regulator -
E5675_RS04110 882985..883503 + 519 WP_136173462.1 GNAT family N-acetyltransferase -
E5675_RS04115 883646..884395 - 750 WP_136173463.1 alpha/beta fold hydrolase -
E5675_RS04120 884439..885614 - 1176 WP_136173464.1 PQQ-dependent sugar dehydrogenase -
E5675_RS04125 885798..886433 - 636 WP_136173465.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(22-171)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-56)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 22283.61 Da        Isoelectric Point: 5.6210

>T123705 WP_136173458.1 NZ_CP039250:c880897-880286 [Sphingopyxis sp. PAMC25046]
MEQAIQTDPARLEAILAFVQAAEKLKDTLRSGITAQGRAESTAEHSWRLCLMTILFDRELGDHDRLKLLKLCIVHDLGEA
ISGDVPATLQVAGDGRAAQERADLMTLCAPLPDDLRDELVALWDEYSAAATPEAILAKGFDKLETMLQHLVGKNGPGFDY
RFNLAYGAKHTARHPLLAQLRALVDRETQKRVIMMAPAEAAKG

Download         Length: 612 bp

>T123705 NZ_CP039250:c880897-880286 [Sphingopyxis sp. PAMC25046]
ATGGAACAGGCCATTCAGACAGATCCCGCCCGGCTCGAAGCCATCCTCGCTTTCGTCCAGGCGGCCGAGAAGCTCAAGGA
TACGCTGCGGAGCGGCATCACCGCGCAGGGCCGCGCCGAGAGTACCGCCGAACATAGCTGGCGGCTCTGCCTGATGACGA
TCTTGTTCGACCGCGAACTGGGCGATCACGACCGCCTCAAACTGCTCAAGCTGTGTATCGTGCACGACCTCGGCGAAGCG
ATTTCGGGCGACGTTCCGGCAACGCTGCAGGTCGCGGGCGACGGACGCGCCGCGCAGGAACGCGCCGATCTGATGACGTT
GTGCGCCCCATTGCCGGACGACCTCCGCGACGAACTCGTCGCGCTGTGGGACGAATATAGCGCAGCCGCCACGCCCGAGG
CGATCCTCGCCAAGGGCTTCGACAAGCTTGAAACCATGCTCCAGCACCTCGTCGGCAAAAATGGCCCCGGCTTCGACTAC
CGGTTCAACCTCGCCTATGGCGCAAAGCATACCGCGCGCCATCCACTGCTCGCGCAATTGCGCGCCCTCGTCGATCGGGA
AACCCAAAAACGCGTGATAATGATGGCGCCGGCCGAGGCAGCTAAAGGCTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19525.17 Da        Isoelectric Point: 10.9013

>AT123705 WP_136173459.1 NZ_CP039250:c881523-880978 [Sphingopyxis sp. PAMC25046]
MTQDLPIGRALRRFRRLNAIKQGHFAELLGVAQASVSRWESGTHEPDAAHREKIAALIAAQTGSDADAALKRLVETSTQA
VHLVCDATHRLLAASPARAASWNADAGTYVGMSLWRFATREIILAEAGLAAAGWFERPFQTLDVRTGANGSREIPVSPGR
MRWETIPLSGGRTGRLTTTLG

Download         Length: 546 bp

>AT123705 NZ_CP039250:c881523-880978 [Sphingopyxis sp. PAMC25046]
ATGACACAGGATCTGCCGATCGGCCGGGCGCTCCGCCGCTTCCGCCGCCTCAACGCCATCAAGCAGGGCCATTTCGCGGA
GCTGCTCGGCGTCGCGCAGGCGAGCGTCTCGCGCTGGGAAAGCGGCACGCACGAGCCCGACGCGGCGCACCGCGAGAAAA
TCGCCGCACTCATCGCCGCGCAGACGGGGAGCGACGCCGATGCCGCGCTCAAACGGTTGGTCGAGACCTCGACGCAGGCG
GTCCACCTCGTCTGTGACGCGACGCACCGCCTGCTCGCGGCGTCGCCCGCGCGCGCGGCGTCGTGGAATGCCGACGCCGG
TACCTATGTCGGCATGTCGCTGTGGCGCTTCGCAACGCGCGAAATCATTCTCGCCGAAGCGGGGCTCGCGGCGGCGGGCT
GGTTCGAGCGCCCGTTCCAGACCCTCGACGTCCGGACCGGCGCCAACGGCAGCCGCGAAATCCCCGTCAGCCCCGGACGG
ATGCGCTGGGAGACCATTCCGCTTTCGGGCGGCCGCACAGGACGCCTGACGACGACGCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References