Detailed information of TA system TA123704

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1356172..1356700
• Replicon: chromosome
• Accession: NZ_CP039249
• Organism: Sphingomonas sp. PAMC26645

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E5673_RS06295
• Protein ID: WP_133031653.1
• Coordinates: 1356172..1356465 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E5673_RS06300
• Protein ID: WP_128454289.1
• Coordinates: 1356452..1356700 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5673_RS06270	1351586..1352929	-	1344	WP_056061736.1	chemotaxis protein	-
E5673_RS06275	1353026..1353607	+	582	WP_136191382.1	succinate dehydrogenase, cytochrome b556 subunit	-
E5673_RS06280	1353607..1353993	+	387	WP_120299369.1	succinate dehydrogenase, hydrophobic membrane anchor protein	-
E5673_RS06285	1353990..1355792	+	1803	WP_136189350.1	succinate dehydrogenase flavoprotein subunit	-
E5673_RS06290	1355792..1356067	+	276	WP_136189351.1	hypothetical protein	-
E5673_RS06295	1356172..1356465	-	294	WP_133031653.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E5673_RS06300	1356452..1356700	-	249	WP_128454289.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
E5673_RS06305	1356800..1357381	+	582	WP_136189352.1	ATP-dependent Clp protease proteolytic subunit	-
E5673_RS06310	1357515..1358309	+	795	WP_136189353.1	succinate dehydrogenase iron-sulfur subunit	-
E5673_RS06315	1358534..1358896	+	363	WP_187504527.1	PaaI family thioesterase	-
E5673_RS06320	1359032..1360123	+	1092	WP_136189355.1	cell division protein ZapE	-
E5673_RS06325	1360251..1361213	+	963	WP_056060667.1	malate dehydrogenase	-
E5673_RS06330	1361304..1361594	+	291	WP_136189356.1	GIY-YIG nuclease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-72)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10895.79 Da
• Isoelectric Point: 10.7294

>T123704 WP_133031653.1 NZ_CP039249:c1356465-1356172 [Sphingomonas sp. PAMC26645]
MATYSLAFLPSALREWEKLGANVREQFKAKLTERLGEPHIASARLSGMTGCYKIKLRAAGYRLVYRVDDGLVTVIVVAVG
RRDRNLVYKIAAGRIER

Nucleotide

• Length: 294 bp

>T123704 NZ_CP039249:c1356465-1356172 [Sphingomonas sp. PAMC26645]
TTGGCGACCTATAGTCTCGCTTTCCTGCCGAGCGCGCTGCGGGAGTGGGAGAAGCTTGGCGCCAATGTTCGCGAGCAGTT
CAAGGCGAAGCTGACCGAGCGGTTGGGCGAGCCACATATTGCGAGTGCGCGGCTGAGCGGAATGACCGGGTGCTACAAGA
TCAAGCTTCGGGCCGCGGGGTATCGGTTGGTGTACCGGGTCGATGATGGCCTGGTGACGGTGATCGTCGTGGCGGTCGGG
CGGCGGGACCGAAATCTGGTGTACAAGATCGCGGCTGGGCGGATCGAGCGGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8625.86 Da
• Isoelectric Point: 4.1220

>AT123704 WP_128454289.1 NZ_CP039249:c1356700-1356452 [Sphingomonas sp. PAMC26645]
MIETIHAGATVSISDLKKNPSGVIEAAGGFPVAVLNRNTPAAYLVPAAAWEELMDRLEDVELAELVRARADEVPVAVSLG
DL

Nucleotide

• Length: 249 bp

>AT123704 NZ_CP039249:c1356700-1356452 [Sphingomonas sp. PAMC26645]
ATGATTGAAACCATCCATGCCGGCGCGACGGTTAGCATCAGCGACCTGAAGAAGAATCCCTCCGGAGTCATCGAGGCTGC
GGGCGGATTCCCAGTGGCGGTGCTTAATCGGAATACGCCCGCCGCGTATCTCGTGCCGGCAGCGGCGTGGGAGGAATTGA
TGGACCGTTTGGAAGACGTCGAACTGGCGGAACTGGTGCGCGCGCGTGCCGACGAGGTGCCGGTCGCGGTGTCGCTTGGC
GACCTATAG