Detailed information of TA system TA123699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 24911..25442
• Replicon: plasmid unnamed4
• Accession: NZ_CP039244
• Organism: Piscirickettsia salmonis strain MR5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PsalMR5_RS23770
• Protein ID: WP_155081895.1
• Coordinates: 25155..25442 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: PsalMR5_RS23765
• Protein ID: WP_122942818.1
• Coordinates: 24911..25165 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PsalMR5_RS23740	20626..21114	+	489	WP_155081893.1	IS30 family transposase	-
PsalMR5_RS23745	21379..22353	+	975	WP_155079741.1	IS30 family transposase	-
PsalMR5_RS23750	22594..23307	-	714	WP_155081894.1	acid phosphatase	-
PsalMR5_RS23755	23394..23498	-	105	Protein_27	transposase	-
PsalMR5_RS23760	23712..24686	-	975	WP_155079445.1	IS30 family transposase	-
PsalMR5_RS23765	24911..25165	+	255	WP_122942818.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
PsalMR5_RS23770	25155..25442	+	288	WP_155081895.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PsalMR5_RS23780	25766..25957	+	192	WP_155079454.1	hypothetical protein	-
PsalMR5_RS23785	26136..26831	+	696	Protein_32	C40 family peptidase	-
PsalMR5_RS23790	26842..28047	-	1206	WP_196215077.1	transposase	-
PsalMR5_RS23795	28337..29722	+	1386	WP_155081897.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..51367	51367

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-55)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11066.13 Da
• Isoelectric Point: 10.8778

>T123699 WP_155081895.1 NZ_CP039244:25155-25442 [Piscirickettsia salmonis]
MTYKLQFHKEAHKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYRIKLRALGYRLIYTVKEDKVVVQVLAIG
SRNRLEAYRLAASRL

Nucleotide

• Length: 288 bp

>T123699 NZ_CP039244:25155-25442 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGCATAAAGAGTGGAAAAAACTGAATCCAACGACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCTTCAGCGGTGTGTGGTGGTGATTTAAAAGGCTGCTATAGAA
TCAAATTAAGAGCGCTCGGTTATCGCTTAATTTATACAGTGAAAGAGGATAAAGTGGTTGTTCAAGTCTTGGCGATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9478.74 Da
• Isoelectric Point: 4.0808

>AT123699 WP_122942818.1 NZ_CP039244:24911-25165 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLNSPDCDFIDVD
VDDL

Nucleotide

• Length: 255 bp

>AT123699 NZ_CP039244:24911-25165 [Piscirickettsia salmonis]
ATGAAACAGCTTTACGCACAACAGTCGGTAACCATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATTAATGAAGCTAA
CGGTGAGCCGGTAGTTATTTTGAATCATAATGTCCCTGCGGCGTATATGGTGCCGCCTGAGCTTTTTGAAGCCATGCTTG
ACTCGTATGAAGACCGCCAACTTGAAGGTATAGTCAAAAAACGTTTGAATTCTCCTGATTGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA