Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 27189..27832 Replicon plasmid unnamed5
Accession NZ_CP039239
Organism Piscirickettsia salmonis strain BI1

Toxin (Protein)


Gene name vapC Uniprot ID E9LHC6
Locus tag PsalBI1_RS24055 Protein ID WP_016210974.1
Coordinates 27189..27596 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L6TI10
Locus tag PsalBI1_RS24060 Protein ID WP_027242932.1
Coordinates 27605..27832 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PsalBI1_RS24020 22521..23345 - 825 WP_196215189.1 phage portal protein -
PsalBI1_RS24025 23347..23508 + 162 WP_155085429.1 hypothetical protein -
PsalBI1_RS24030 23434..23805 - 372 WP_155085436.1 phage portal protein -
PsalBI1_RS24035 23892..24869 - 978 WP_155081942.1 terminase large subunit -
PsalBI1_RS24040 24907..25881 - 975 WP_155079741.1 IS30 family transposase -
PsalBI1_RS24045 25941..26171 - 231 WP_155081943.1 hypothetical protein -
PsalBI1_RS24050 26392..27177 - 786 WP_155081944.1 DNA/RNA non-specific endonuclease -
PsalBI1_RS24055 27189..27596 - 408 WP_016210974.1 DUF4411 family protein Toxin
PsalBI1_RS24060 27605..27832 - 228 WP_027242932.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PsalBI1_RS24065 27980..28345 - 366 WP_155081945.1 hypothetical protein -
PsalBI1_RS24070 28494..28964 - 471 WP_155081946.1 single-stranded DNA-binding protein -
PsalBI1_RS24075 28968..29198 - 231 WP_155081947.1 hypothetical protein -
PsalBI1_RS24080 29195..29542 - 348 WP_155085437.1 hypothetical protein -
PsalBI1_RS24085 29535..29873 - 339 WP_155081949.1 hypothetical protein -
PsalBI1_RS24090 30005..31192 - 1188 WP_155085430.1 replication initiation protein -
PsalBI1_RS24095 31300..31560 - 261 WP_155085431.1 hypothetical protein -
PsalBI1_RS24100 31677..31979 - 303 WP_155081953.1 hypothetical protein -
PsalBI1_RS24105 32319..32777 + 459 WP_155081954.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..44011 44011


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-126)

Antitoxin

SpoVT-AbrB domain

(7-41)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15625.00 Da        Isoelectric Point: 7.4170

>T123696 WP_016210974.1 NZ_CP039239:c27596-27189 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLEVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVEHLEFEDWAS

Download         Length: 408 bp

>T123696 NZ_CP039239:c27596-27189 [Piscirickettsia salmonis]
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAGCCTCGTTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCCATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGGAGTCAAC
ACCAGCGAAAAAACCAGGAAGCGATTAATACCTTGGTAAATAAGCTAGAAGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCGCATGC
GCTCTCAGAAAAAGCTGTTCTAGTAACGCATAATACAAAAGAGTTTCAGCGTGTCGAGCATTTAGAGTTTGAAGACTGGG
CAAGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8948.07 Da        Isoelectric Point: 4.5700

>AT123696 WP_027242932.1 NZ_CP039239:c27832-27605 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDRQDIQAQERDWF

Download         Length: 228 bp

>AT123696 NZ_CP039239:c27832-27605 [Piscirickettsia salmonis]
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCCCAAGCCGTTCGGTTACCGAAAGAAATGCGGCTGGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCACATGC
CGGATGTATCGGATGATTTTATGGAAGATCGCCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LHC6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI10

References