Detailed information of TA system TA123694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 33280..33811
• Replicon: plasmid unnamed3
• Accession: NZ_CP039237
• Organism: Piscirickettsia salmonis strain BI1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PsalBI1_RS23220
• Protein ID: WP_155081895.1
• Coordinates: 33524..33811 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: PsalBI1_RS23215
• Protein ID: WP_122942818.1
• Coordinates: 33280..33534 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PsalBI1_RS23185	28707..29195	+	489	WP_155081893.1	IS30 family transposase	-
PsalBI1_RS23190	29460..30434	+	975	WP_155079741.1	IS30 family transposase	-
PsalBI1_RS23195	30675..31388	-	714	WP_155081894.1	acid phosphatase	-
PsalBI1_RS23200	31475..31579	-	105	Protein_37	transposase	-
PsalBI1_RS23205	31793..32128	-	336	Protein_38	IS30 family transposase	-
PsalBI1_RS23210	32417..33055	-	639	Protein_39	IS30 family transposase	-
PsalBI1_RS23215	33280..33534	+	255	WP_122942818.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
PsalBI1_RS23220	33524..33811	+	288	WP_155081895.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PsalBI1_RS23230	34135..34326	+	192	WP_155079454.1	hypothetical protein	-
PsalBI1_RS23235	34505..35200	+	696	Protein_43	C40 family peptidase	-
PsalBI1_RS23240	35211..36452	-	1242	WP_155081896.1	transposase	-
PsalBI1_RS23245	36706..38091	+	1386	WP_155081897.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..66296	66296

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-55)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11066.13 Da
• Isoelectric Point: 10.8778

>T123694 WP_155081895.1 NZ_CP039237:33524-33811 [Piscirickettsia salmonis]
MTYKLQFHKEAHKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYRIKLRALGYRLIYTVKEDKVVVQVLAIG
SRNRLEAYRLAASRL

Nucleotide

• Length: 288 bp

>T123694 NZ_CP039237:33524-33811 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGCATAAAGAGTGGAAAAAACTGAATCCAACGACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCTTCAGCGGTGTGTGGTGGTGATTTAAAAGGCTGCTATAGAA
TCAAATTAAGAGCGCTCGGTTATCGCTTAATTTATACAGTGAAAGAGGATAAAGTGGTTGTTCAAGTCTTGGCGATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9478.74 Da
• Isoelectric Point: 4.0808

>AT123694 WP_122942818.1 NZ_CP039237:33280-33534 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLNSPDCDFIDVD
VDDL

Nucleotide

• Length: 255 bp

>AT123694 NZ_CP039237:33280-33534 [Piscirickettsia salmonis]
ATGAAACAGCTTTACGCACAACAGTCGGTAACCATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATTAATGAAGCTAA
CGGTGAGCCGGTAGTTATTTTGAATCATAATGTCCCTGCGGCGTATATGGTGCCGCCTGAGCTTTTTGAAGCCATGCTTG
ACTCGTATGAAGACCGCCAACTTGAAGGTATAGTCAAAAAACGTTTGAATTCTCCTGATTGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA