Detailed information of TA system TA123691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 24910..25441
• Replicon: plasmid unnamed4
• Accession: NZ_CP039231
• Organism: Piscirickettsia salmonis strain SR1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PsalSR1_RS23935
• Protein ID: WP_155081895.1
• Coordinates: 25154..25441 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: PsalSR1_RS23930
• Protein ID: WP_122942818.1
• Coordinates: 24910..25164 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PsalSR1_RS23905	20625..21113	+	489	WP_155081893.1	IS30 family transposase	-
PsalSR1_RS23910	21378..22352	+	975	WP_155079741.1	IS30 family transposase	-
PsalSR1_RS23915	22593..23306	-	714	WP_155081894.1	acid phosphatase	-
PsalSR1_RS23920	23393..23497	-	105	Protein_27	transposase	-
PsalSR1_RS23925	23711..24685	-	975	WP_155079445.1	IS30 family transposase	-
PsalSR1_RS23930	24910..25164	+	255	WP_122942818.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
PsalSR1_RS23935	25154..25441	+	288	WP_155081895.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PsalSR1_RS23945	25765..25956	+	192	WP_155079454.1	hypothetical protein	-
PsalSR1_RS23950	26135..26830	+	696	Protein_32	C40 family peptidase	-
PsalSR1_RS25605	26884..27718	-	835	Protein_33	IS630 family transposase	-
PsalSR1_RS23965	27785..28321	+	537	Protein_34	IS6 family transposase	-
PsalSR1_RS23970	28376..28534	+	159	Protein_35	hypothetical protein	-
PsalSR1_RS23975	28684..29472	+	789	WP_155079983.1	IS30 family transposase	-
PsalSR1_RS23980	29476..29724	-	249	WP_155080231.1	hypothetical protein	-
PsalSR1_RS23985	29780..30088	+	309	WP_155079958.1	hypothetical protein	-
PsalSR1_RS23990	30085..30435	+	351	WP_155079959.1	IS66 family insertion sequence element accessory protein TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..56994	56994

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-55)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11066.13 Da
• Isoelectric Point: 10.8778

>T123691 WP_155081895.1 NZ_CP039231:25154-25441 [Piscirickettsia salmonis]
MTYKLQFHKEAHKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYRIKLRALGYRLIYTVKEDKVVVQVLAIG
SRNRLEAYRLAASRL

Nucleotide

• Length: 288 bp

>T123691 NZ_CP039231:25154-25441 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGCATAAAGAGTGGAAAAAACTGAATCCAACGACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCTTCAGCGGTGTGTGGTGGTGATTTAAAAGGCTGCTATAGAA
TCAAATTAAGAGCGCTCGGTTATCGCTTAATTTATACAGTGAAAGAGGATAAAGTGGTTGTTCAAGTCTTGGCGATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9478.74 Da
• Isoelectric Point: 4.0808

>AT123691 WP_122942818.1 NZ_CP039231:24910-25164 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLNSPDCDFIDVD
VDDL

Nucleotide

• Length: 255 bp

>AT123691 NZ_CP039231:24910-25164 [Piscirickettsia salmonis]
ATGAAACAGCTTTACGCACAACAGTCGGTAACCATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATTAATGAAGCTAA
CGGTGAGCCGGTAGTTATTTTGAATCATAATGTCCCTGCGGCGTATATGGTGCCGCCTGAGCTTTTTGAAGCCATGCTTG
ACTCGTATGAAGACCGCCAACTTGAAGGTATAGTCAAAAAACGTTTGAATTCTCCTGATTGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA