Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 93471..94041 Replicon plasmid unnamed1
Accession NZ_CP039220
Organism Piscirickettsia salmonis strain NVI 5692

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PsalN5692_RS18300 Protein ID WP_155068857.1
Coordinates 93471..93797 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PsalN5692_RS18305 Protein ID WP_155068858.1
Coordinates 93799..94041 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PsalN5692_RS18255 88730..89437 - 708 WP_155068853.1 IS6 family transposase -
PsalN5692_RS18260 89538..89864 - 327 WP_155068854.1 type II toxin-antitoxin system PemK/MazF family toxin -
PsalN5692_RS18265 89866..90051 - 186 WP_155068855.1 toxin-antitoxin system, antitoxin component, AbrB family protein -
PsalN5692_RS18270 90115..90507 + 393 Protein_118 IS6 family transposase -
PsalN5692_RS18275 90547..91383 - 837 WP_155047317.1 IS3 family transposase -
PsalN5692_RS18280 91395..91667 - 273 WP_032126239.1 transposase -
PsalN5692_RS18285 91739..92077 + 339 Protein_121 DDE-type integrase/transposase/recombinase -
PsalN5692_RS18290 92066..92794 - 729 WP_155068842.1 IS6 family transposase -
PsalN5692_RS18295 92841..93359 - 519 WP_155068856.1 ISAs1 family transposase -
PsalN5692_RS18300 93471..93797 - 327 WP_155068857.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PsalN5692_RS18305 93799..94041 - 243 WP_155068858.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PsalN5692_RS18310 94247..94552 + 306 WP_196215520.1 hypothetical protein -
PsalN5692_RS18315 94589..95317 + 729 WP_155068842.1 IS6 family transposase -
PsalN5692_RS18320 95411..96010 + 600 WP_155068859.1 ISAs1 family transposase -
PsalN5692_RS18325 96045..96233 + 189 Protein_129 hypothetical protein -
PsalN5692_RS18330 96439..97167 - 729 WP_017375910.1 IS6 family transposase -
PsalN5692_RS18335 97299..97472 + 174 WP_155068860.1 hypothetical protein -
PsalN5692_RS18340 97492..98466 - 975 WP_155066440.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..137059 137059
- inside IScluster/Tn - - 77956..134613 56657


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12104.91 Da        Isoelectric Point: 8.9893

>T123683 WP_155068857.1 NZ_CP039220:c93797-93471 [Piscirickettsia salmonis]
VPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKLYNSKVGLVTGCPVTSKIKGYPFEVELPKNNNVHGAVLVNQLTTKDFR
ARDWNHADKIDKKSLERVQELIDVMLNG

Download         Length: 327 bp

>T123683 NZ_CP039220:c93797-93471 [Piscirickettsia salmonis]
GTGCCTGAACGGGGTGATATTATTTTTCTTAGCTTAGATCCTACGTTAGGTAGTGAACAAAGAGGAAATCGACCTTTTTT
GGTGTTAACTTCTAAGCTTTATAACTCAAAGGTTGGGCTTGTGACTGGATGCCCGGTTACTTCAAAAATTAAAGGATATC
CTTTTGAAGTTGAGTTACCTAAAAACAATAACGTTCATGGTGCAGTGCTAGTTAACCAACTCACTACGAAAGATTTTCGT
GCTAGGGATTGGAATCATGCTGACAAAATTGATAAAAAATCACTTGAAAGAGTTCAGGAGTTGATTGACGTGATGCTCAA
TGGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8935.08 Da        Isoelectric Point: 4.5907

>AT123683 WP_155068858.1 NZ_CP039220:c94041-93799 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTINKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEDLGGERFE

Download         Length: 243 bp

>AT123683 NZ_CP039220:c94041-93799 [Piscirickettsia salmonis]
ATGGATGCAGTTGTTAGAAAATGGGGAAATAGTTTGGGGTTGTTACTCCCCTTGAGCATTGCGCGCGAACTTCATATCAA
TGATGGTAGTCATGTGACGATTAATAAGGTCGGGGATGAGATTCACATCAAGCCTTTGACTCATACGCAGACCCTAGAAT
TATTATTATCAGAAATTACCCCTGAAAATAGTCATGATTTAGTTGATTGGGGTGAAGACTTAGGGGGGGAACGCTTTGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References