Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 37976..38546 Replicon plasmid unnamed1
Accession NZ_CP039215
Organism Piscirickettsia salmonis strain Psal-104a

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Psal104a_RS16690 Protein ID WP_129556708.1
Coordinates 37976..38311 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Psal104a_RS16695 Protein ID WP_016212365.1
Coordinates 38304..38546 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal104a_RS16655 33652..34029 + 378 Protein_43 DDE-type integrase/transposase/recombinase -
Psal104a_RS16660 34130..34909 + 780 WP_081377351.1 transposase -
Psal104a_RS16670 35098..35430 + 333 WP_032126739.1 transposase -
Psal104a_RS16675 35595..35972 + 378 WP_016212154.1 DDE-type integrase/transposase/recombinase -
Psal104a_RS16680 36279..36662 - 384 WP_016212152.1 hypothetical protein -
Psal104a_RS16685 37132..37860 - 729 WP_054300202.1 IS6 family transposase -
Psal104a_RS16690 37976..38311 - 336 WP_129556708.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Psal104a_RS16695 38304..38546 - 243 WP_016212365.1 antidote-toxin recognition MazE family protein Antitoxin
Psal104a_RS16700 38755..39729 + 975 WP_054300271.1 IS30 family transposase -
Psal104a_RS16705 39857..40297 + 441 Protein_52 tyrosine-type recombinase/integrase -
Psal104a_RS16710 40365..41093 + 729 WP_075275142.1 IS6 family transposase -
Psal104a_RS16715 41376..43061 + 1686 WP_075275141.1 protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..153780 153780
- inside IScluster/Tn - - 11619..44801 33182


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12345.36 Da        Isoelectric Point: 10.3188

>T123678 WP_129556708.1 NZ_CP039215:c38311-37976 [Piscirickettsia salmonis]
MNKVPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKPYNLKVGLVTGCPVTSKIKGYPFEVEIPKNNSVHGAVLVNQLTTK
DFRARGWNHADKLDKKSLERVQGLIDVMLKG

Download         Length: 336 bp

>T123678 NZ_CP039215:c38311-37976 [Piscirickettsia salmonis]
TTGAATAAAGTGCCTGAACGTGGTGATATTATTTTTCTTAGTTTAGACCCTACATTAGGTAGTGAACAAAGAGGAAACCG
ACCCTTTTTAGTGTTGACTTCCAAGCCCTATAACTTAAAGGTGGGACTTGTGACGGGGTGCCCGGTTACTTCAAAGATTA
AAGGATATCCTTTTGAAGTTGAGATACCTAAAAACAATAGCGTTCACGGAGCAGTGTTGGTTAACCAACTAACAACAAAA
GATTTCCGTGCTAGGGGCTGGAATCATGCTGATAAGCTCGATAAAAAATCTCTTGAAAGAGTTCAGGGGCTAATTGATGT
GATGTTGAAAGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.09 Da        Isoelectric Point: 4.4750

>AT123678 WP_016212365.1 NZ_CP039215:c38546-38304 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTIDKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEELGGERFE

Download         Length: 243 bp

>AT123678 NZ_CP039215:c38546-38304 [Piscirickettsia salmonis]
ATGGATGCAGTTGTTAGAAAATGGGGGAATAGCTTGGGGTTGTTGCTACCCTTGAGCATCGCACGTGAACTTCATATCAA
TGATGGTAGTCATGTGACGATTGATAAGGTCGGGGATGAGATTCACATTAAACCTTTGACTCATACGCAGACCCTTGAAT
TATTATTATCAGAAATTACCCCTGAAAATAGTCATGATTTAGTAGATTGGGGTGAAGAATTAGGAGGGGAGCGCTTTGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References