Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 6030..6588 Replicon plasmid unnamed3
Accession NZ_CP039212
Organism Piscirickettsia salmonis strain Psal-103

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag Psal103_RS17750 Protein ID WP_155047328.1
Coordinates 6030..6242 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag Psal103_RS17755 Protein ID WP_155047327.1
Coordinates 6235..6588 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal103_RS17725 1367..2413 - 1047 WP_027243195.1 hypothetical protein -
Psal103_RS17730 2739..3701 - 963 WP_036773142.1 IS91 family transposase -
Psal103_RS17735 3626..3865 - 240 WP_080963666.1 transposase zinc-binding domain-containing protein -
Psal103_RS17740 4323..4652 + 330 WP_155047329.1 hypothetical protein -
Psal103_RS17745 5012..5986 + 975 WP_054300271.1 IS30 family transposase -
Psal103_RS17750 6030..6242 + 213 WP_155047328.1 type II toxin-antitoxin system HicA family toxin Toxin
Psal103_RS17755 6235..6588 + 354 WP_155047327.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Psal103_RS17760 6658..8037 + 1380 WP_155047326.1 MFS transporter -
Psal103_RS17765 8058..8783 - 726 WP_016210975.1 ester cyclase -
Psal103_RS17770 8860..9615 - 756 WP_016210971.1 methyltransferase domain-containing protein -
Psal103_RS18510 9872..10024 + 153 WP_162034504.1 hypothetical protein -
Psal103_RS17775 10284..10589 + 306 WP_016210958.1 hypothetical protein -
Psal103_RS17780 10743..11042 + 300 WP_016210976.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..38376 38376


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(7-66)

Antitoxin

Uncharacterised protein family HicB

(53-103)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7691.99 Da        Isoelectric Point: 10.5676

>T123676 WP_155047328.1 NZ_CP039212:6030-6242 [Piscirickettsia salmonis]
IKASIVWADIEKLLLALGAEVIERDGSRVAVILNQVKTTFHRPHPEKTTDKGAVKSIRLFLKNAGVDKNA

Download         Length: 213 bp

>T123676 NZ_CP039212:6030-6242 [Piscirickettsia salmonis]
ATCAAAGCAAGCATTGTTTGGGCTGATATAGAAAAGCTTCTTTTAGCGTTAGGGGCTGAAGTAATAGAGCGTGATGGTTC
AAGGGTTGCTGTCATTTTGAATCAAGTGAAAACAACATTTCATAGACCGCACCCTGAAAAAACAACAGACAAGGGGGCGG
TTAAGTCAATAAGGTTGTTTTTAAAAAATGCTGGAGTAGATAAAAATGCTTAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13476.43 Da        Isoelectric Point: 5.0200

>AT123676 WP_155047327.1 NZ_CP039212:6235-6588 [Piscirickettsia salmonis]
MLKYKGYIGKVEEIHEGDEYIYGIVPNIKDVISFKGKNIKELTKDFKLAIDDYLALCDEREEEPDKPFSGRFMTRLGSDL
HEEVFLASMNDSGAKSMNDWVVSACLEKLKHDQIVKR

Download         Length: 354 bp

>AT123676 NZ_CP039212:6235-6588 [Piscirickettsia salmonis]
ATGCTTAAATACAAAGGTTATATTGGAAAAGTTGAAGAGATTCATGAAGGTGATGAATATATTTATGGGATTGTTCCAAA
TATTAAAGATGTTATTTCTTTTAAAGGTAAAAATATAAAAGAGTTAACGAAAGACTTTAAGCTGGCTATTGATGATTATT
TGGCTTTATGTGATGAGCGTGAAGAAGAACCCGATAAACCATTTTCTGGTAGATTTATGACTAGATTAGGTAGTGATTTG
CATGAAGAGGTTTTTTTAGCTTCTATGAATGATTCAGGTGCAAAATCAATGAATGATTGGGTTGTATCTGCATGCTTGGA
AAAGTTGAAGCATGATCAAATCGTTAAACGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References