Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 5655..6261 Replicon plasmid unnamed2
Accession NZ_CP039206
Organism Piscirickettsia salmonis strain Psal-182

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B8UI87
Locus tag Psal182_RS17155 Protein ID WP_027242955.1
Coordinates 5655..5915 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7U4WZG4
Locus tag Psal182_RS17160 Protein ID WP_016211078.1
Coordinates 5908..6261 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal182_RS17125 1010..2290 + 1281 WP_155085010.1 hypothetical protein -
Psal182_RS17130 2786..2929 + 144 WP_188322436.1 hypothetical protein -
Psal182_RS17135 2972..3205 + 234 WP_036781101.1 hypothetical protein -
Psal182_RS17140 3252..3686 + 435 WP_054300686.1 hypothetical protein -
Psal182_RS17145 3916..4890 + 975 WP_054300271.1 IS30 family transposase -
Psal182_RS17150 5101..5430 + 330 WP_155085011.1 hypothetical protein -
Psal182_RS17155 5655..5915 + 261 WP_027242955.1 type II toxin-antitoxin system HicA family toxin Toxin
Psal182_RS17160 5908..6261 + 354 WP_016211078.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Psal182_RS17165 6365..7165 + 801 WP_016211074.1 methyltransferase domain-containing protein -
Psal182_RS17170 7162..7974 - 813 WP_016211068.1 LuxR C-terminal-related transcriptional regulator -
Psal182_RS17175 7978..9219 - 1242 WP_016211075.1 MFS transporter -
Psal182_RS17180 9434..9577 + 144 WP_155047030.1 hypothetical protein -
Psal182_RS17185 9602..10033 + 432 WP_016211069.1 hypothetical protein -
Psal182_RS17190 10017..10802 + 786 WP_155085012.1 queuosine precursor transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..53285 53285


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(53-103)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9695.31 Da        Isoelectric Point: 10.9468

>T123670 WP_027242955.1 NZ_CP039206:5655-5915 [Piscirickettsia salmonis]
MNNKHRKTLRDIFHNPIKASIVWADIEKLLLALGAEVIERDGSRVAVILNQVKTTFHRPHPEKTTDKGAVKSIRLFLKNA
GVDKNA

Download         Length: 261 bp

>T123670 NZ_CP039206:5655-5915 [Piscirickettsia salmonis]
ATGAATAATAAACATCGTAAGACACTAAGAGATATTTTTCATAACCCGATCAAAGCAAGCATTGTTTGGGCTGATATAGA
AAAGCTTCTTTTAGCGTTAGGGGCTGAAGTAATAGAGCGTGATGGTTCAAGGGTTGCTGTAATTTTGAATCAAGTGAAAA
CAACATTTCATAGACCGCACCCTGAAAAAACAACAGACAAGGGGGCGGTTAAGTCAATAAGGTTGTTTTTAAAAAATGCT
GGAGTAGATAAAAATGCTTAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13492.39 Da        Isoelectric Point: 5.0200

>AT123670 WP_016211078.1 NZ_CP039206:5908-6261 [Piscirickettsia salmonis]
MLKYKGYIGKVEEIHEGDEYIYGIVPNIKDVISFRGKNIKELTKDFKLAIDDYLALCDEREEEPDKPFSGRFMTRLGSDL
HEEVFLASMNDSGAKSMNDWVVSACLEKLKHDQTVKR

Download         Length: 354 bp

>AT123670 NZ_CP039206:5908-6261 [Piscirickettsia salmonis]
ATGCTTAAATACAAAGGTTATATTGGAAAAGTTGAAGAGATTCATGAAGGTGATGAATATATTTATGGGATTGTTCCAAA
TATTAAAGATGTTATTTCTTTTAGAGGTAAAAATATAAAAGAGTTAACGAAAGACTTTAAGCTGGCTATTGATGATTATT
TGGCTTTATGTGATGAGCGTGAAGAAGAACCCGATAAACCATTTTCTGGTAGATTTATGACTAGATTAGGTAGTGATTTG
CATGAAGAGGTTTTTTTAGCTTCTATGAATGATTCAGGTGCAAAATCAATGAATGATTGGGTTGTATCTGCATGCTTGGA
AAAGTTAAAGCATGATCAAACCGTTAAACGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B8UI87

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4WZG4

References