Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 67334..67865 Replicon plasmid unnamed1
Accession NZ_CP039177
Organism Piscirickettsia salmonis strain Psal-139

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag Psal139_RS16590 Protein ID WP_027243212.1
Coordinates 67578..67865 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag Psal139_RS16585 Protein ID WP_027243211.1
Coordinates 67334..67588 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal139_RS16555 63059..64039 + 981 WP_144420849.1 hypothetical protein -
Psal139_RS16560 64121..64465 - 345 Protein_84 DDE-type integrase/transposase/recombinase -
Psal139_RS16565 64505..65482 - 978 WP_036771347.1 IS5 family transposase -
Psal139_RS16570 65678..65866 + 189 Protein_86 hypothetical protein -
Psal139_RS16575 65963..66940 + 978 WP_036771347.1 IS5 family transposase -
Psal139_RS16580 66955..67116 + 162 WP_155046636.1 hypothetical protein -
Psal139_RS16585 67334..67588 + 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Psal139_RS16590 67578..67865 + 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Psal139_RS16595 67872..68333 - 462 Protein_91 tail assembly protein -
Psal139_RS16600 68360..69337 - 978 WP_036771347.1 IS5 family transposase -
Psal139_RS16605 69670..70164 - 495 Protein_93 hypothetical protein -
Psal139_RS16610 70133..70249 - 117 Protein_94 phage minor tail protein L -
Psal139_RS16615 70338..70550 + 213 WP_053093683.1 hypothetical protein -
Psal139_RS16620 70708..71685 + 978 WP_036771347.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..175590 175590


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T123646 WP_027243212.1 NZ_CP039177:67578-67865 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T123646 NZ_CP039177:67578-67865 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT123646 WP_027243211.1 NZ_CP039177:67334-67588 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT123646 NZ_CP039177:67334-67588 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References