Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 793594..794071 Replicon chromosome
Accession NZ_CP039167
Organism Staphylococcus aureus strain R50

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E1952_RS03970 Protein ID WP_000052076.1
Coordinates 793594..793782 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E1952_RS03975 Protein ID WP_001059690.1
Coordinates 793811..794071 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1952_RS03940 789584..790105 + 522 WP_000824487.1 hypothetical protein -
E1952_RS03945 790446..791132 + 687 WP_001793574.1 thermonuclease family protein -
E1952_RS03950 791489..791689 + 201 WP_001059082.1 cold-shock protein -
E1952_RS03955 792185..792403 - 219 WP_000005886.1 hypothetical protein -
E1952_RS03960 792465..792749 - 285 WP_001004399.1 hypothetical protein -
E1952_RS03965 792837..793406 - 570 WP_001106652.1 hypothetical protein -
E1952_RS03970 793594..793782 - 189 WP_000052076.1 hypothetical protein Toxin
E1952_RS03975 793811..794071 - 261 WP_001059690.1 hypothetical protein Antitoxin
E1952_RS03980 794412..794615 + 204 WP_000145164.1 sterile alpha motif-like domain-containing protein -
E1952_RS03985 794612..794848 - 237 WP_000368687.1 hypothetical protein -
E1952_RS03990 795073..795654 + 582 WP_001140695.1 phosphoglycerate mutase family protein -
E1952_RS03995 795727..796344 - 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
E1952_RS04000 796499..796993 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E1952_RS04005 797392..797814 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
E1952_RS04010 797962..798678 + 717 WP_000150016.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T123616 WP_000052076.1 NZ_CP039167:c793782-793594 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T123616 NZ_CP039167:c793782-793594 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT123616 WP_001059690.1 NZ_CP039167:c794071-793811 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT123616 NZ_CP039167:c794071-793811 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References