Detailed information of TA system TA123615

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 766136..766665
• Replicon: chromosome
• Accession: NZ_CP039167
• Organism: Staphylococcus aureus strain R50

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX6
• Locus tag: E1952_RS03820
• Protein ID: WP_001103939.1
• Coordinates: 766348..766665 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IA75
• Locus tag: E1952_RS03815
• Protein ID: WP_001058492.1
• Coordinates: 766136..766345 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1952_RS03780	762466..762930	+	465	WP_001085185.1	SsrA-binding protein SmpB	-
E1952_RS03790	763493..764599	-	1107	WP_000149511.1	site-specific integrase	-
E1952_RS03795	764589..765392	-	804	WP_000358990.1	helix-turn-helix domain-containing protein	-
E1952_RS03800	765528..765731	+	204	WP_001045296.1	transcriptional regulator	-
E1952_RS03805	765767..765985	+	219	WP_000163544.1	helix-turn-helix domain-containing protein	-
E1952_RS03810	765997..766143	+	147	WP_000784885.1	hypothetical protein	-
E1952_RS03815	766136..766345	+	210	WP_001058492.1	hypothetical protein	Antitoxin
E1952_RS03820	766348..766665	+	318	WP_001103939.1	DUF1474 family protein	Toxin
E1952_RS03825	766728..767597	+	870	WP_001002717.1	primase alpha helix C-terminal domain-containing protein	-
E1952_RS03830	767614..769071	+	1458	WP_000390453.1	virulence-associated E family protein	-
E1952_RS03835	769380..769742	+	363	WP_001039170.1	hypothetical protein	-
E1952_RS03840	769744..770028	+	285	WP_000998185.1	hypothetical protein	-
E1952_RS03845	770025..770666	+	642	WP_001019807.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12547.17 Da
• Isoelectric Point: 5.0161

>T123615 WP_001103939.1 NZ_CP039167:766348-766665 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T123615 NZ_CP039167:766348-766665 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT123615 WP_001058492.1 NZ_CP039167:766136-766345 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT123615 NZ_CP039167:766136-766345 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: K7ZRX6

Antitoxin

• AlphaFold DB: X5IA75