Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 759497..759974 Replicon chromosome
Accession NZ_CP039162
Organism Staphylococcus aureus strain Lr12

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E1950_RS03745 Protein ID WP_000052076.1
Coordinates 759497..759685 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E1950_RS03750 Protein ID WP_001059690.1
Coordinates 759714..759974 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1950_RS03715 755491..756012 + 522 WP_000824482.1 hypothetical protein -
E1950_RS03720 756353..757039 + 687 WP_103152312.1 thermonuclease family protein -
E1950_RS03725 757396..757596 + 201 WP_001059082.1 cold-shock protein -
E1950_RS03730 758088..758306 - 219 WP_103152313.1 hypothetical protein -
E1950_RS03735 758368..758652 - 285 WP_001004399.1 hypothetical protein -
E1950_RS03740 758740..759309 - 570 WP_001106654.1 hypothetical protein -
E1950_RS03745 759497..759685 - 189 WP_000052076.1 hypothetical protein Toxin
E1950_RS03750 759714..759974 - 261 WP_001059690.1 hypothetical protein Antitoxin
E1950_RS03755 760315..760518 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E1950_RS03760 760515..760751 - 237 WP_000349581.1 hypothetical protein -
E1950_RS03765 760976..761557 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
E1950_RS03770 761630..762247 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
E1950_RS03775 762402..762896 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E1950_RS03785 763295..763717 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
E1950_RS03790 763865..764581 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T123600 WP_000052076.1 NZ_CP039162:c759685-759497 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T123600 NZ_CP039162:c759685-759497 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT123600 WP_001059690.1 NZ_CP039162:c759974-759714 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT123600 NZ_CP039162:c759974-759714 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References