123560

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 851911..852388 Replicon chromosome
Accession NZ_CP039156
Organism Staphylococcus aureus strain WCUH29

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E5491_RS04210 Protein ID WP_000052076.1
Coordinates 851911..852099 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E5491_RS04215 Protein ID WP_001059690.1
Coordinates 852128..852388 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5491_RS04180 847905..848426 + 522 WP_000824482.1 hypothetical protein -
E5491_RS04185 848767..849453 + 687 WP_000141557.1 thermonuclease family protein -
E5491_RS04190 849810..850010 + 201 WP_001059082.1 cold-shock protein -
E5491_RS04195 850502..850720 - 219 WP_000005886.1 hypothetical protein -
E5491_RS04200 850782..851066 - 285 WP_001004399.1 hypothetical protein -
E5491_RS04205 851154..851723 - 570 WP_001106654.1 hypothetical protein -
E5491_RS04210 851911..852099 - 189 WP_000052076.1 hypothetical protein Toxin
E5491_RS04215 852128..852388 - 261 WP_001059690.1 hypothetical protein Antitoxin
E5491_RS04220 852729..852932 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E5491_RS04225 852929..853165 - 237 WP_000349581.1 hypothetical protein -
E5491_RS04230 853390..853971 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
E5491_RS04235 854044..854661 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
E5491_RS04240 854816..855310 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E5491_RS04245 855709..856131 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
E5491_RS04250 856279..856995 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T123560 WP_000052076.1 NZ_CP039156:c852099-851911 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T123560 NZ_CP039156:c852099-851911 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT123560 WP_001059690.1 NZ_CP039156:c852388-852128 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT123560 NZ_CP039156:c852388-852128 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References