Detailed information of TA system TA123559

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 392304..392839
• Replicon: chromosome
• Accession: NZ_CP039156
• Organism: Staphylococcus aureus strain WCUH29

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A4P7P340
• Locus tag: E5491_RS01835
• Protein ID: WP_001103945.1
• Coordinates: 392516..392839 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: E5491_RS01830
• Protein ID: WP_001058486.1
• Coordinates: 392304..392513 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5491_RS01795	387517..387759	+	243	WP_000897044.1	30S ribosomal protein S18	-
E5491_RS01800	387875..388981	-	1107	WP_000715303.1	Abi family protein	-
E5491_RS01805	389162..390373	-	1212	WP_000270133.1	site-specific integrase	-
E5491_RS01810	390829..391524	-	696	WP_000668213.1	helix-turn-helix domain-containing protein	-
E5491_RS01815	391668..391880	+	213	WP_000794656.1	helix-turn-helix transcriptional regulator	-
E5491_RS01820	391881..392153	+	273	WP_000091734.1	helix-turn-helix domain-containing protein	-
E5491_RS01825	392165..392311	+	147	WP_031824147.1	hypothetical protein	-
E5491_RS01830	392304..392513	+	210	WP_001058486.1	hypothetical protein	Antitoxin
E5491_RS01835	392516..392839	+	324	WP_001103945.1	DUF1474 family protein	Toxin
E5491_RS01840	392904..393773	+	870	WP_001002724.1	primase alpha helix C-terminal domain-containing protein	-
E5491_RS01845	393787..395496	+	1710	WP_000447455.1	DUF927 domain-containing protein	-
E5491_RS01850	395809..396189	+	381	WP_000356939.1	hypothetical protein	-
E5491_RS01855	396186..396827	+	642	WP_001019767.1	hypothetical protein	-
E5491_RS01860	397277..397618	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	386962..409064	22102

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12665.26 Da
• Isoelectric Point: 4.7124

>T123559 WP_001103945.1 NZ_CP039156:392516-392839 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKNSIKVAE

Nucleotide

• Length: 324 bp

>T123559 NZ_CP039156:392516-392839 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGA
GTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT123559 WP_001058486.1 NZ_CP039156:392304-392513 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT123559 NZ_CP039156:392304-392513 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGTGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: A0A4P7P340