Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 61213..61741 Replicon plasmid p10FS3-1-2
Accession NZ_CP039145
Organism Acinetobacter sp. 10FS3-1

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag E5Y90_RS16165 Protein ID WP_000221358.1
Coordinates 61448..61741 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9B5Q7
Locus tag E5Y90_RS16160 Protein ID WP_000246756.1
Coordinates 61213..61458 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5Y90_RS16140 56726..58246 + 1521 WP_174660665.1 aldehyde dehydrogenase -
E5Y90_RS16145 58303..59460 + 1158 WP_174660666.1 iron-containing alcohol dehydrogenase -
E5Y90_RS16150 59897..60487 - 591 WP_174660667.1 recombinase family protein -
E5Y90_RS16155 60717..61109 + 393 WP_174660668.1 hypothetical protein -
E5Y90_RS16160 61213..61458 + 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E5Y90_RS16165 61448..61741 + 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E5Y90_RS16170 61855..62109 + 255 WP_174660669.1 hypothetical protein -
E5Y90_RS16180 63371..63589 - 219 Protein_45 GntP family permease -
E5Y90_RS16185 63722..64492 + 771 WP_174660670.1 IclR family transcriptional regulator -
E5Y90_RS16190 65092..66675 + 1584 WP_174660671.1 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..75189 75189


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T123551 WP_000221358.1 NZ_CP039145:61448-61741 [Acinetobacter sp. 10FS3-1]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T123551 NZ_CP039145:61448-61741 [Acinetobacter sp. 10FS3-1]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCTAAAGTCATAGAGCAGCCACATATTCCAAAGAACATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGATTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9235.61 Da        Isoelectric Point: 4.3142

>AT123551 WP_000246756.1 NZ_CP039145:61213-61458 [Acinetobacter sp. 10FS3-1]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT123551 NZ_CP039145:61213-61458 [Acinetobacter sp. 10FS3-1]
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCCGTCAAAAAAGCTTTGCTTTCGGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAACGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB N9B5Q7

References