123548

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 5771108..5772837 Replicon chromosome
Accession NZ_CP039127
Organism Pseudomonas sp. A2

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag E5221_RS26625 Protein ID WP_135001746.1
Coordinates 5772196..5772837 (-) Length 214 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag E5221_RS26620 Protein ID WP_182328840.1
Coordinates 5771108..5772196 (-) Length 363 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5221_RS26605 (E5221_27590) 5766993..5767532 + 540 WP_247846683.1 type 1 glutamine amidotransferase domain-containing protein -
E5221_RS26610 (E5221_27595) 5767735..5768931 + 1197 WP_013974648.1 class I SAM-dependent rRNA methyltransferase -
E5221_RS26615 (E5221_27600) 5769203..5771044 + 1842 WP_025340988.1 dihydroxy-acid dehydratase -
E5221_RS26620 (E5221_27605) 5771108..5772196 - 1089 WP_182328840.1 macro domain-containing protein Antitoxin
E5221_RS26625 (E5221_27610) 5772196..5772837 - 642 WP_135001746.1 DUF4433 domain-containing protein Toxin
E5221_RS26630 (E5221_27615) 5772834..5773412 - 579 WP_182328839.1 DarT ssDNA thymidine ADP-ribosyltransferase family protein -
E5221_RS26635 (E5221_27620) 5773511..5774566 - 1056 WP_182328838.1 haloacid dehalogenase-like hydrolase -
E5221_RS26640 (E5221_27625) 5774811..5776202 + 1392 WP_182328837.1 L-cystine transporter -
E5221_RS26645 (E5221_27630) 5776344..5776859 - 516 WP_039612552.1 dihydrofolate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-213)

Antitoxin

Macro domain

(18-130)


Sequences

Toxin        


Download         Length: 214 a.a.        Molecular weight: 24646.16 Da        Isoelectric Point: 8.6888

>T123548 WP_135001746.1 NZ_CP039127:c5772837-5772196 [Pseudomonas sp. A2]
MIYTSLNPSKALIWRIVHRDNLPWLLDHGLHAVSSGRLSNAYVGIGNPDLISKRAQRNVPIEPNGTLADYVPFYFTPFSV
MMKNIHSGWSVQQRRNEEIVILVSSLYHAQSLGLRFVFTDAHAYPHWAGYYSDLAQLDKIDWEILQRRDFKRDPDDPRKM
ERYQAEALIYGHVPVAGLLGIVCYNEALKSRVDKEVQQRQLDLPVHARPGWYF

Download         Length: 642 bp

>T123548 NZ_CP039127:c5772837-5772196 [Pseudomonas sp. A2]
ATGATTTATACCAGTCTTAACCCATCCAAAGCGCTGATCTGGCGAATTGTTCATCGCGATAACCTGCCGTGGCTTCTGGA
CCATGGGTTGCATGCGGTCTCCTCCGGGAGGCTGTCCAACGCTTACGTTGGGATCGGCAATCCTGATCTGATCAGCAAGC
GAGCTCAACGCAACGTGCCTATTGAACCCAACGGAACACTTGCAGACTATGTGCCTTTCTACTTCACTCCGTTTTCGGTG
ATGATGAAGAACATCCACTCGGGTTGGAGTGTTCAGCAGCGGCGGAACGAAGAGATCGTGATTCTTGTCTCCAGCCTGTA
CCATGCCCAATCGCTGGGCCTGCGTTTTGTGTTCACAGATGCCCATGCTTACCCGCATTGGGCCGGCTACTACAGCGATC
TCGCGCAGCTGGACAAAATCGATTGGGAGATTCTGCAACGCAGGGACTTCAAGCGTGATCCTGATGACCCTCGAAAAATG
GAGCGTTATCAGGCTGAGGCCCTTATCTATGGACATGTCCCGGTCGCTGGCCTTTTGGGAATTGTCTGCTACAACGAAGC
TTTGAAGAGTCGTGTCGACAAGGAGGTTCAGCAACGTCAGCTGGATCTCCCCGTGCATGCTCGTCCTGGGTGGTACTTCT
GA

Antitoxin


Download         Length: 363 a.a.        Molecular weight: 40511.67 Da        Isoelectric Point: 5.9417

>AT123548 WP_182328840.1 NZ_CP039127:c5772196-5771108 [Pseudomonas sp. A2]
MIRFMQGNLLEAKADALVNTVNTVGVMGKGIALMFKERFVENYRQYAAACKAKEVITGKMFVTEVCELDGPRWIVNFPTK
RHWRSPSQIGWIIDGLHDLRRFIIENQVASIAIPPLGAGNGGLPWTAVREQIEGILDDLSADILVFEPTGNYQNVSKRSG
VETLTPARALIAELVRRYWVLGMECSLLEIQKLAWFLERSIEQFTPGINPLELKFVAHKYGPYANRLEHLLDNLDGSYLH
CGKRISDAGPLDVIWFDEGRKTFVQAYLNSEAKAYLPALEFTADLIDGFESPFGMELLATVDWLLYEEGVEPTVPAVREH
LKKWSGGAGAAVRKSRLFDDESLGIALQKLSVFRSGTVSPLH

Download         Length: 1089 bp

>AT123548 NZ_CP039127:c5772196-5771108 [Pseudomonas sp. A2]
ATGATCCGCTTCATGCAAGGTAACCTGCTGGAGGCCAAGGCCGACGCGCTGGTTAATACAGTCAACACCGTAGGGGTGAT
GGGAAAAGGCATCGCGCTAATGTTTAAGGAGCGCTTTGTCGAAAACTATCGCCAGTACGCTGCTGCCTGCAAAGCGAAAG
AAGTAATTACCGGAAAGATGTTTGTTACGGAAGTGTGCGAGCTGGACGGGCCGCGATGGATTGTGAATTTCCCTACCAAG
CGGCATTGGCGTTCACCTTCACAAATTGGTTGGATCATTGACGGGTTGCATGACCTGCGCCGCTTTATTATTGAGAACCA
GGTGGCTTCGATCGCTATCCCTCCTCTTGGCGCAGGCAATGGAGGATTGCCTTGGACTGCGGTGCGCGAGCAGATTGAGG
GTATTCTGGATGATTTGAGTGCCGATATTCTCGTTTTCGAACCCACTGGAAATTACCAAAACGTATCCAAGCGCAGTGGT
GTTGAGACGTTGACCCCTGCTCGTGCATTGATCGCAGAACTGGTGCGCCGTTATTGGGTATTGGGCATGGAGTGCAGCTT
GCTTGAGATCCAGAAGCTAGCCTGGTTTCTGGAGCGATCAATTGAGCAATTCACCCCGGGCATCAATCCACTGGAGTTGA
AATTTGTCGCTCATAAATATGGCCCTTACGCCAACCGTCTTGAGCACCTTCTAGACAATCTGGACGGAAGCTATTTGCAC
TGCGGAAAGCGGATTAGCGACGCAGGTCCTCTCGATGTGATTTGGTTCGATGAGGGGCGCAAAACATTTGTGCAGGCGTA
TTTGAACAGTGAAGCCAAAGCCTATTTGCCTGCGCTGGAGTTTACTGCTGATTTGATCGATGGCTTCGAGTCTCCATTTG
GAATGGAGCTTCTGGCTACGGTTGACTGGCTATTGTATGAAGAGGGTGTTGAGCCGACAGTCCCAGCAGTTCGAGAACAC
CTCAAGAAATGGTCGGGAGGGGCAGGTGCTGCTGTACGGAAAAGCAGATTGTTTGATGATGAGTCACTTGGAATAGCTCT
TCAAAAGCTATCAGTATTTCGCTCGGGTACAGTTTCTCCGCTTCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References