Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-higA/HigB-HigA
Location 343322..344195 Replicon chromosome
Accession NZ_CP039127
Organism Pseudomonas sp. A2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag E5221_RS01565 Protein ID WP_102083354.1
Coordinates 343322..343675 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E5221_RS01570 Protein ID WP_061550697.1
Coordinates 343722..344195 (+) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5221_RS01550 (E5221_01585) 339338..340057 - 720 WP_015268622.1 response regulator -
E5221_RS01555 (E5221_01590) 340198..342495 + 2298 WP_247846792.1 TonB-dependent siderophore receptor -
E5221_RS01560 (E5221_01595) 342938..343144 - 207 WP_082810501.1 DUF3079 domain-containing protein -
E5221_RS01565 (E5221_01600) 343322..343675 + 354 WP_102083354.1 type II toxin-antitoxin system HigB family toxin Toxin
E5221_RS01570 (E5221_01605) 343722..344195 + 474 WP_061550697.1 transcriptional regulator Antitoxin
E5221_RS01575 (E5221_01610) 344719..345702 + 984 WP_122048507.1 hypothetical protein -
E5221_RS01580 (E5221_01615) 345725..346690 - 966 WP_163002516.1 SGNH/GDSL hydrolase family protein -
E5221_RS01585 (E5221_01620) 346687..348414 - 1728 WP_122048505.1 SGNH/GDSL hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(73-111)

Antitoxin

Antitoxin HigA

(43-154)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13588.73 Da        Isoelectric Point: 10.4174

>T123541 WP_102083354.1 NZ_CP039127:343322-343675 [Pseudomonas sp. A2]
MRVITKAAVTKAIEAHAQWKAPLSLWLTTFDRATLRFESFEQLRNTWSTASGWNVDRIPCSKLRPSSRKGPLDVYVFDIK
KNECRLIAWLNTRTGTLYIKAILSHAEYDKWCKSDVR

Download         Length: 354 bp

>T123541 NZ_CP039127:343322-343675 [Pseudomonas sp. A2]
ATGCGGGTGATAACGAAAGCGGCGGTTACCAAAGCCATCGAAGCTCACGCCCAGTGGAAAGCCCCCCTGAGCCTGTGGCT
CACGACCTTTGATAGGGCGACGCTGCGCTTCGAGTCTTTTGAGCAGCTAAGGAATACGTGGTCTACCGCCTCTGGCTGGA
ACGTTGACCGCATTCCTTGTTCAAAACTCAGACCCTCCAGCCGAAAAGGGCCGCTTGATGTCTATGTGTTCGATATCAAG
AAAAACGAATGCCGTCTGATCGCATGGCTCAACACACGAACGGGCACCCTCTATATCAAGGCCATTCTGTCGCACGCGGA
GTACGACAAGTGGTGCAAGAGCGATGTCAGGTAG

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17198.66 Da        Isoelectric Point: 4.5725

>AT123541 WP_061550697.1 NZ_CP039127:343722-344195 [Pseudomonas sp. A2]
MKRDKIEANGLDAFIANISPMLDGLNAQMATMAQLLAACHDPIKDDAELQARMALIDELYSHADSEGHAAARFAEMVADR
VYEYESESVLVPFASQAEALAFLLSDRGVKQKDLASIATQSAVSEILNNKRKMTVAQIKGFAEFFSVPVEFFMHGVV

Download         Length: 474 bp

>AT123541 NZ_CP039127:343722-344195 [Pseudomonas sp. A2]
ATGAAGCGGGATAAAATCGAAGCCAATGGACTAGATGCCTTCATCGCTAATATTTCACCCATGCTGGATGGCCTGAACGC
CCAGATGGCAACCATGGCCCAGCTTCTTGCTGCCTGCCATGACCCTATCAAGGACGATGCAGAGCTCCAGGCGCGGATGG
CATTGATCGATGAACTCTACTCGCATGCCGACAGCGAAGGTCACGCAGCAGCGCGCTTTGCGGAGATGGTGGCGGATCGT
GTCTACGAGTATGAGAGTGAGTCGGTACTCGTGCCGTTTGCGAGCCAGGCCGAAGCGTTGGCCTTCCTGCTGTCGGACAG
GGGCGTGAAGCAGAAGGACCTTGCCTCGATAGCGACCCAGAGTGCGGTTTCAGAGATTCTGAACAACAAGCGGAAGATGA
CGGTTGCCCAGATAAAGGGCTTTGCTGAGTTTTTCAGCGTGCCGGTCGAGTTTTTCATGCATGGGGTGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References