Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 65030..65561 Replicon plasmid unnamed1
Accession NZ_CP039113
Organism Piscirickettsia salmonis strain Psal-135

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag Psal135_RS16555 Protein ID WP_027243212.1
Coordinates 65274..65561 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag Psal135_RS16550 Protein ID WP_027243211.1
Coordinates 65030..65284 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal135_RS16520 60755..61735 + 981 WP_144420849.1 hypothetical protein -
Psal135_RS16525 61817..62161 - 345 Protein_81 DDE-type integrase/transposase/recombinase -
Psal135_RS16530 62201..63178 - 978 WP_036771347.1 IS5 family transposase -
Psal135_RS16535 63374..63562 + 189 Protein_83 hypothetical protein -
Psal135_RS16540 63659..64636 + 978 WP_036771347.1 IS5 family transposase -
Psal135_RS16545 64651..64812 + 162 WP_155046636.1 hypothetical protein -
Psal135_RS16550 65030..65284 + 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Psal135_RS16555 65274..65561 + 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Psal135_RS16560 65568..66029 - 462 Protein_88 tail assembly protein -
Psal135_RS16565 66056..67033 - 978 WP_036771347.1 IS5 family transposase -
Psal135_RS16570 67145..68167 + 1023 WP_027243215.1 hypothetical protein -
Psal135_RS16575 68240..68581 + 342 Protein_91 IS6 family transposase -
Psal135_RS16580 68650..69378 - 729 WP_036774350.1 IS6 family transposase -
Psal135_RS16585 69448..70053 + 606 Protein_93 IS982 family transposase -
Psal135_RS16590 70336..70506 + 171 Protein_94 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..186021 186021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T123537 WP_027243212.1 NZ_CP039113:65274-65561 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T123537 NZ_CP039113:65274-65561 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT123537 WP_027243211.1 NZ_CP039113:65030-65284 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT123537 NZ_CP039113:65030-65284 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References