Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 98565..99096 Replicon plasmid unnamed1
Accession NZ_CP039098
Organism Piscirickettsia salmonis strain Psal-117

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag Psal117_RS16790 Protein ID WP_027243212.1
Coordinates 98565..98852 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag Psal117_RS16795 Protein ID WP_027243211.1
Coordinates 98842..99096 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal117_RS16760 94745..95722 - 978 WP_036771347.1 IS5 family transposase -
Psal117_RS16765 95880..96092 - 213 WP_053093683.1 hypothetical protein -
Psal117_RS16770 96181..96297 + 117 Protein_125 phage minor tail protein L -
Psal117_RS16775 96266..96760 + 495 Protein_126 hypothetical protein -
Psal117_RS16780 97093..98070 + 978 WP_036771347.1 IS5 family transposase -
Psal117_RS16785 98097..98558 + 462 Protein_128 tail assembly protein -
Psal117_RS16790 98565..98852 - 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Psal117_RS16795 98842..99096 - 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Psal117_RS16800 99314..99475 - 162 WP_155046636.1 hypothetical protein -
Psal117_RS16805 99490..100467 - 978 WP_036771347.1 IS5 family transposase -
Psal117_RS16810 100564..100752 - 189 Protein_133 hypothetical protein -
Psal117_RS16815 100948..101925 + 978 WP_036771347.1 IS5 family transposase -
Psal117_RS16820 101965..102309 + 345 Protein_135 DDE-type integrase/transposase/recombinase -
Psal117_RS16825 102391..103371 - 981 WP_144420849.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..168649 168649


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T123517 WP_027243212.1 NZ_CP039098:c98852-98565 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T123517 NZ_CP039098:c98852-98565 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT123517 WP_027243211.1 NZ_CP039098:c99096-98842 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT123517 NZ_CP039098:c99096-98842 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References