Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 74883..75414 Replicon plasmid unnamed1
Accession NZ_CP039082
Organism Piscirickettsia salmonis strain Psal-110

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag Psal110_RS16625 Protein ID WP_027243212.1
Coordinates 75127..75414 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag Psal110_RS16620 Protein ID WP_027243211.1
Coordinates 74883..75137 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal110_RS16590 70608..71588 + 981 WP_144420849.1 hypothetical protein -
Psal110_RS16595 71670..72014 - 345 Protein_95 DDE-type integrase/transposase/recombinase -
Psal110_RS16600 72054..73031 - 978 WP_036771347.1 IS5 family transposase -
Psal110_RS16605 73227..73415 + 189 Protein_97 hypothetical protein -
Psal110_RS16610 73512..74489 + 978 WP_036771347.1 IS5 family transposase -
Psal110_RS16615 74504..74665 + 162 WP_155046636.1 hypothetical protein -
Psal110_RS16620 74883..75137 + 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Psal110_RS16625 75127..75414 + 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Psal110_RS16630 75421..75882 - 462 Protein_102 tail assembly protein -
Psal110_RS16635 75909..76886 - 978 WP_036771347.1 IS5 family transposase -
Psal110_RS16640 76916..78064 - 1149 WP_048876196.1 hypothetical protein -
Psal110_RS16645 78591..79490 + 900 Protein_105 IS30 family transposase -
Psal110_RS16650 79526..79687 - 162 Protein_106 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..177162 177162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T123501 WP_027243212.1 NZ_CP039082:75127-75414 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T123501 NZ_CP039082:75127-75414 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT123501 WP_027243211.1 NZ_CP039082:74883-75137 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT123501 NZ_CP039082:74883-75137 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References