Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 54572..55215 Replicon plasmid unnamed1
Accession NZ_CP039082
Organism Piscirickettsia salmonis strain Psal-110

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L6TI66
Locus tag Psal110_RS16500 Protein ID WP_027242931.1
Coordinates 54808..55215 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L6TI10
Locus tag Psal110_RS16495 Protein ID WP_027242932.1
Coordinates 54572..54799 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal110_RS16465 50420..50827 - 408 WP_036817201.1 AAA family ATPase -
Psal110_RS16470 50935..51978 - 1044 WP_017375960.1 NAD(P)-dependent alcohol dehydrogenase -
Psal110_RS16475 52280..52513 + 234 WP_017375959.1 type II toxin-antitoxin system RelE/ParE family toxin -
Psal110_RS16480 52651..52800 - 150 WP_196214251.1 hypothetical protein -
Psal110_RS16485 52866..53195 + 330 WP_162038692.1 HigA family addiction module antidote protein -
Psal110_RS16490 54074..54439 + 366 WP_026063496.1 hypothetical protein -
Psal110_RS16495 54572..54799 + 228 WP_027242932.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Psal110_RS16500 54808..55215 + 408 WP_027242931.1 DUF4411 family protein Toxin
Psal110_RS16505 55361..56743 + 1383 WP_027242930.1 hypothetical protein -
Psal110_RS16510 56933..57136 + 204 WP_017375952.1 hypothetical protein -
Psal110_RS16515 57332..57715 + 384 WP_027242929.1 HNH endonuclease -
Psal110_RS16520 57802..58284 + 483 WP_075278733.1 P27 family phage terminase small subunit -
Psal110_RS16525 58287..59618 + 1332 WP_048876205.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..177162 177162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(7-41)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15562.93 Da        Isoelectric Point: 7.4168

>T123500 WP_027242931.1 NZ_CP039082:54808-55215 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLDVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVDHLELEDWAS

Download         Length: 408 bp

>T123500 NZ_CP039082:54808-55215 [Piscirickettsia salmonis]
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAACCTCGCTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCGATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGCAGTCAAC
ACCAGCGAAAAAATCAGGAAGCAATTAATACCTTGGTGAATAAGCTCGATGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCACATGC
GCTTTCAGAAAAGGCTGTTTTAGTAACGCATAATACAAAAGAGTTTCAGCGTGTCGATCATTTAGAGCTTGAAGACTGGG
CAAGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8948.07 Da        Isoelectric Point: 4.5700

>AT123500 WP_027242932.1 NZ_CP039082:54572-54799 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDRQDIQAQERDWF

Download         Length: 228 bp

>AT123500 NZ_CP039082:54572-54799 [Piscirickettsia salmonis]
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCTCAAGCCGTTCGATTACCGAAAGAAATGCGCCTTGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCATATGC
CGGATGTATCGGATGATTTTATGGAGGATCGCCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TI66

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI10

References