Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 68440..68971 Replicon plasmid unnamed2
Accession NZ_CP039078
Organism Piscirickettsia salmonis strain Psal-109

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag Psal109_RS16940 Protein ID WP_027243212.1
Coordinates 68684..68971 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag Psal109_RS16935 Protein ID WP_027243211.1
Coordinates 68440..68694 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal109_RS16905 64165..65145 + 981 WP_144420849.1 hypothetical protein -
Psal109_RS16910 65227..65571 - 345 Protein_85 DDE-type integrase/transposase/recombinase -
Psal109_RS16915 65611..66588 - 978 WP_036771347.1 IS5 family transposase -
Psal109_RS16920 66784..66972 + 189 Protein_87 hypothetical protein -
Psal109_RS16925 67069..68046 + 978 WP_036771347.1 IS5 family transposase -
Psal109_RS16930 68061..68222 + 162 WP_155046636.1 hypothetical protein -
Psal109_RS16935 68440..68694 + 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Psal109_RS16940 68684..68971 + 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Psal109_RS16945 68978..69439 - 462 Protein_92 tail assembly protein -
Psal109_RS16950 69466..70443 - 978 WP_036771347.1 IS5 family transposase -
Psal109_RS16955 70776..71270 - 495 Protein_94 hypothetical protein -
Psal109_RS16960 71239..71355 - 117 Protein_95 phage minor tail protein L -
Psal109_RS16965 71444..71656 + 213 WP_053093683.1 hypothetical protein -
Psal109_RS16970 71814..72791 + 978 WP_036771347.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..176236 176236


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T123496 WP_027243212.1 NZ_CP039078:68684-68971 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T123496 NZ_CP039078:68684-68971 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT123496 WP_027243211.1 NZ_CP039078:68440-68694 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT123496 NZ_CP039078:68440-68694 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References