Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 105534..106065 Replicon plasmid unnamed1
Accession NZ_CP039061
Organism Piscirickettsia salmonis strain Psal-099

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag Psal099_RS16855 Protein ID WP_027243212.1
Coordinates 105534..105821 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag Psal099_RS16860 Protein ID WP_027243211.1
Coordinates 105811..106065 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal099_RS16825 101714..102691 - 978 WP_036771347.1 IS5 family transposase -
Psal099_RS16830 102849..103061 - 213 WP_053093683.1 hypothetical protein -
Psal099_RS16835 103150..103266 + 117 Protein_131 phage minor tail protein L -
Psal099_RS16840 103235..103729 + 495 Protein_132 hypothetical protein -
Psal099_RS16845 104062..105039 + 978 WP_036771347.1 IS5 family transposase -
Psal099_RS16850 105066..105527 + 462 Protein_134 tail assembly protein -
Psal099_RS16855 105534..105821 - 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Psal099_RS16860 105811..106065 - 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Psal099_RS16865 106283..106444 - 162 WP_155046636.1 hypothetical protein -
Psal099_RS16870 106459..107436 - 978 WP_036771347.1 IS5 family transposase -
Psal099_RS16875 108046..108411 + 366 WP_026063496.1 hypothetical protein -
Psal099_RS16880 108544..108771 + 228 WP_027242932.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
Psal099_RS16885 108780..109187 + 408 WP_027242931.1 DUF4411 family protein -
Psal099_RS16890 109333..110715 + 1383 WP_027242930.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..175441 175441


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T123477 WP_027243212.1 NZ_CP039061:c105821-105534 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T123477 NZ_CP039061:c105821-105534 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT123477 WP_027243211.1 NZ_CP039061:c106065-105811 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT123477 NZ_CP039061:c106065-105811 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References