Detailed information of TA system TA123473

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 68457..68988
• Replicon: plasmid unnamed1
• Accession: NZ_CP039056
• Organism: Piscirickettsia salmonis strain Psal-098

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7U4YYE1
• Locus tag: Psal098_RS16635
• Protein ID: WP_027243212.1
• Coordinates: 68701..68988 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1L6TI86
• Locus tag: Psal098_RS16630
• Protein ID: WP_027243211.1
• Coordinates: 68457..68711 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Psal098_RS16600	63816..64043	-	228	WP_027242932.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
Psal098_RS16605	64176..64541	-	366	WP_026063496.1	hypothetical protein	-
Psal098_RS16610	65628..66605	-	978	WP_036771347.1	IS5 family transposase	-
Psal098_RS16615	66801..66989	+	189	Protein_87	hypothetical protein	-
Psal098_RS16620	67086..68063	+	978	WP_036771347.1	IS5 family transposase	-
Psal098_RS16625	68078..68239	+	162	WP_155046636.1	hypothetical protein	-
Psal098_RS16630	68457..68711	+	255	WP_027243211.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
Psal098_RS16635	68701..68988	+	288	WP_027243212.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Psal098_RS16640	68995..69456	-	462	Protein_92	tail assembly protein	-
Psal098_RS16645	69483..70460	-	978	WP_036771347.1	IS5 family transposase	-
Psal098_RS16650	70793..70984	-	192	Protein_94	sulfite exporter TauE/SafE family protein	-
Psal098_RS18680	70984..71124	+	141	WP_157894756.1	hypothetical protein	-
Psal098_RS16655	71386..72246	+	861	WP_017377526.1	LysR family transcriptional regulator	-
Psal098_RS16660	72576..73310	+	735	WP_027243210.1	IS6 family transposase	-
Psal098_RS16665	73724..73987	+	264	WP_047927763.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..175317	175317

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-55)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11063.21 Da
• Isoelectric Point: 10.8855

>T123473 WP_027243212.1 NZ_CP039056:68701-68988 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Nucleotide

• Length: 288 bp

>T123473 NZ_CP039056:68701-68988 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9554.83 Da
• Isoelectric Point: 4.3176

>AT123473 WP_027243211.1 NZ_CP039056:68457-68711 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Nucleotide

• Length: 255 bp

>AT123473 NZ_CP039056:68457-68711 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A7U4YYE1

Antitoxin

• AlphaFold DB: A0A1L6TI86