Detailed information of TA system TA123467

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 79853..80387
• Replicon: plasmid unnamed1
• Accession: NZ_CP039051
• Organism: Piscirickettsia salmonis strain Psal-081

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Psal081_RS16560
• Protein ID: WP_048876199.1
• Coordinates: 80097..80387 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1L6TI86
• Locus tag: Psal081_RS16555
• Protein ID: WP_027243211.1
• Coordinates: 79853..80107 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Psal081_RS16525	75578..76558	+	981	WP_144420849.1	hypothetical protein	-
Psal081_RS16530	76640..76984	-	345	Protein_102	DDE-type integrase/transposase/recombinase	-
Psal081_RS16535	77024..78001	-	978	WP_036771347.1	IS5 family transposase	-
Psal081_RS16540	78197..78385	+	189	Protein_104	hypothetical protein	-
Psal081_RS16545	78482..79459	+	978	WP_036771347.1	IS5 family transposase	-
Psal081_RS16550	79474..79635	+	162	WP_155046636.1	hypothetical protein	-
Psal081_RS16555	79853..80107	+	255	WP_027243211.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
Psal081_RS16560	80097..80387	+	291	WP_048876199.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Psal081_RS16565	80374..81351	-	978	WP_036771347.1	IS5 family transposase	-
Psal081_RS16570	81684..82178	-	495	Protein_110	hypothetical protein	-
Psal081_RS16575	82147..82263	-	117	Protein_111	phage minor tail protein L	-
Psal081_RS16580	82352..82564	+	213	WP_053093683.1	hypothetical protein	-
Psal081_RS16585	82722..83699	+	978	WP_036771347.1	IS5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..179546	179546

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-55)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11119.33 Da
• Isoelectric Point: 10.5762

>T123467 WP_048876199.1 NZ_CP039051:80097-80387 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLARR
CCVTSGPIFQAQFSCV

Nucleotide

• Length: 291 bp

>T123467 NZ_CP039051:80097-80387 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCAGGCGT
TGTTGCGTAACCTCTGGTCCCATATTCCAGGCACAATTCAGCTGCGTCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9554.83 Da
• Isoelectric Point: 4.3176

>AT123467 WP_027243211.1 NZ_CP039051:79853-80107 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Nucleotide

• Length: 255 bp

>AT123467 NZ_CP039051:79853-80107 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1L6TI86