Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 137601..138244 Replicon plasmid unnamed1
Accession NZ_CP039047
Organism Piscirickettsia salmonis strain Psal-073

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L6TI66
Locus tag Psal073_RS16885 Protein ID WP_027242931.1
Coordinates 137601..138008 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L6TI10
Locus tag Psal073_RS16890 Protein ID WP_027242932.1
Coordinates 138017..138244 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal073_RS16860 132847..134529 - 1683 WP_155069805.1 terminase large subunit -
Psal073_RS16865 134532..135014 - 483 WP_075278733.1 P27 family phage terminase small subunit -
Psal073_RS16870 135101..135484 - 384 WP_027242929.1 HNH endonuclease -
Psal073_RS16875 135680..135883 - 204 WP_017375952.1 hypothetical protein -
Psal073_RS16880 136073..137455 - 1383 WP_027242930.1 hypothetical protein -
Psal073_RS16885 137601..138008 - 408 WP_027242931.1 DUF4411 family protein Toxin
Psal073_RS16890 138017..138244 - 228 WP_027242932.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Psal073_RS16895 138458..139432 + 975 WP_036771332.1 IS30 family transposase -
Psal073_RS16900 139483..139848 - 366 WP_026063496.1 hypothetical protein -
Psal073_RS16905 140067..140219 - 153 WP_155069807.1 hypothetical protein -
Psal073_RS16910 140684..141013 - 330 WP_162038692.1 HigA family addiction module antidote protein -
Psal073_RS16915 141079..141228 + 150 WP_196214251.1 hypothetical protein -
Psal073_RS16920 141373..141939 + 567 WP_017375966.1 HAMP domain-containing histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..208052 208052


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(7-41)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15562.93 Da        Isoelectric Point: 7.4168

>T123462 WP_027242931.1 NZ_CP039047:c138008-137601 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLDVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVDHLELEDWAS

Download         Length: 408 bp

>T123462 NZ_CP039047:c138008-137601 [Piscirickettsia salmonis]
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAACCTCGCTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCGATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGCAGTCAAC
ACCAGCGAAAAAATCAGGAAGCAATTAATACCTTGGTGAATAAGCTCGATGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCACATGC
GCTTTCAGAAAAGGCTGTTTTAGTAACGCATAATACAAAAGAGTTTCAGCGTGTCGATCATTTAGAGCTTGAAGACTGGG
CAAGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8948.07 Da        Isoelectric Point: 4.5700

>AT123462 WP_027242932.1 NZ_CP039047:c138244-138017 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDRQDIQAQERDWF

Download         Length: 228 bp

>AT123462 NZ_CP039047:c138244-138017 [Piscirickettsia salmonis]
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCTCAAGCCGTTCGATTACCGAAAGAAATGCGCCTTGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCATATGC
CGGATGTATCGGATGATTTTATGGAGGATCGCCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TI66

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI10

References