Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 32491..33049 Replicon plasmid unnamed4
Accession NZ_CP039044
Organism Piscirickettsia salmonis strain Psal-072

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag Psal072_RS19345 Protein ID WP_155047328.1
Coordinates 32837..33049 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag Psal072_RS19340 Protein ID WP_155047327.1
Coordinates 32491..32844 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal072_RS19315 28037..28336 - 300 WP_016210976.1 hypothetical protein -
Psal072_RS19320 28490..28795 - 306 WP_016210958.1 hypothetical protein -
Psal072_RS19880 29055..29207 - 153 WP_162034504.1 hypothetical protein -
Psal072_RS19325 29464..30219 + 756 WP_016210971.1 methyltransferase domain-containing protein -
Psal072_RS19330 30296..31021 + 726 WP_016210975.1 ester cyclase -
Psal072_RS19335 31042..32421 - 1380 WP_155047326.1 MFS transporter -
Psal072_RS19340 32491..32844 - 354 WP_155047327.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Psal072_RS19345 32837..33049 - 213 WP_155047328.1 type II toxin-antitoxin system HicA family toxin Toxin
Psal072_RS19350 33093..34067 - 975 WP_054300271.1 IS30 family transposase -
Psal072_RS19355 34427..34756 - 330 WP_155047329.1 hypothetical protein -
Psal072_RS19360 35214..35453 + 240 WP_080963666.1 transposase zinc-binding domain-containing protein -
Psal072_RS19365 35378..36340 + 963 WP_036773142.1 IS91 family transposase -
Psal072_RS19370 36666..37712 + 1047 WP_027243195.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..38376 38376


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(7-66)

Antitoxin

Uncharacterised protein family HicB

(53-103)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7691.99 Da        Isoelectric Point: 10.5676

>T123459 WP_155047328.1 NZ_CP039044:c33049-32837 [Piscirickettsia salmonis]
IKASIVWADIEKLLLALGAEVIERDGSRVAVILNQVKTTFHRPHPEKTTDKGAVKSIRLFLKNAGVDKNA

Download         Length: 213 bp

>T123459 NZ_CP039044:c33049-32837 [Piscirickettsia salmonis]
ATCAAAGCAAGCATTGTTTGGGCTGATATAGAAAAGCTTCTTTTAGCGTTAGGGGCTGAAGTAATAGAGCGTGATGGTTC
AAGGGTTGCTGTCATTTTGAATCAAGTGAAAACAACATTTCATAGACCGCACCCTGAAAAAACAACAGACAAGGGGGCGG
TTAAGTCAATAAGGTTGTTTTTAAAAAATGCTGGAGTAGATAAAAATGCTTAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13476.43 Da        Isoelectric Point: 5.0200

>AT123459 WP_155047327.1 NZ_CP039044:c32844-32491 [Piscirickettsia salmonis]
MLKYKGYIGKVEEIHEGDEYIYGIVPNIKDVISFKGKNIKELTKDFKLAIDDYLALCDEREEEPDKPFSGRFMTRLGSDL
HEEVFLASMNDSGAKSMNDWVVSACLEKLKHDQIVKR

Download         Length: 354 bp

>AT123459 NZ_CP039044:c32844-32491 [Piscirickettsia salmonis]
ATGCTTAAATACAAAGGTTATATTGGAAAAGTTGAAGAGATTCATGAAGGTGATGAATATATTTATGGGATTGTTCCAAA
TATTAAAGATGTTATTTCTTTTAAAGGTAAAAATATAAAAGAGTTAACGAAAGACTTTAAGCTGGCTATTGATGATTATT
TGGCTTTATGTGATGAGCGTGAAGAAGAACCCGATAAACCATTTTCTGGTAGATTTATGACTAGATTAGGTAGTGATTTG
CATGAAGAGGTTTTTTTAGCTTCTATGAATGATTCAGGTGCAAAATCAATGAATGATTGGGTTGTATCTGCATGCTTGGA
AAAGTTGAAGCATGATCAAATCGTTAAACGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References