Detailed information of TA system TA123448

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2968082..2968610
• Replicon: chromosome
• Accession: NZ_CP039031
• Organism: Acinetobacter indicus strain yy_1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9N871
• Locus tag: E5093_RS14140
• Protein ID: WP_000221358.1
• Coordinates: 2968082..2968375 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E5093_RS14145
• Protein ID: WP_160232258.1
• Coordinates: 2968365..2968610 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5093_RS14120	2963935..2964810	-	876	WP_177156115.1	pirin family protein	-
E5093_RS14125	2965012..2965575	-	564	WP_005180661.1	alkyl hydroperoxide reductase subunit C	-
E5093_RS14130	2966287..2967377	-	1091	Protein_2722	IS3 family transposase	-
E5093_RS14135	2967624..2967953	+	330	WP_004641881.1	four-helix bundle copper-binding protein	-
E5093_RS14140	2968082..2968375	-	294	WP_000221358.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E5093_RS14145	2968365..2968610	-	246	WP_160232258.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E5093_RS14150	2968790..2969734	-	945	WP_004668309.1	copper resistance protein B	-
E5093_RS14155	2969721..2970059	-	339	WP_177156116.1	hypothetical protein	-
E5093_RS14160	2970046..2971857	-	1812	WP_177156117.1	copper resistance system multicopper oxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11292.52 Da
• Isoelectric Point: 10.4753

>T123448 WP_000221358.1 NZ_CP039031:c2968375-2968082 [Acinetobacter indicus]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T123448 NZ_CP039031:c2968375-2968082 [Acinetobacter indicus]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9279.66 Da
• Isoelectric Point: 4.3142

>AT123448 WP_160232258.1 NZ_CP039031:c2968610-2968365 [Acinetobacter indicus]
MATVNFRIDEALKEKSYSILKEQGITPTDFFTSILEYVATTGKLPVKKALISEEDEELLALVRKRINDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT123448 NZ_CP039031:c2968610-2968365 [Acinetobacter indicus]
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTACACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGATTTCAGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Structures

Toxin

• AlphaFold DB: A0A6A1RKP4