Detailed information of TA system TA123446

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2633880..2634405
• Replicon: chromosome
• Accession: NZ_CP039031
• Organism: Acinetobacter indicus strain yy_1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E5093_RS12470
• Protein ID: WP_177156014.1
• Coordinates: 2633880..2634167 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E5093_RS12475
• Protein ID: WP_104488392.1
• Coordinates: 2634157..2634405 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5093_RS12450	2629271..2630035	-	765	WP_177156010.1	hypothetical protein	-
E5093_RS12455	2631379..2631591	-	213	WP_177156011.1	hypothetical protein	-
E5093_RS12460	2631823..2632401	+	579	WP_177156012.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-
E5093_RS12465	2632432..2633727	+	1296	WP_177156013.1	Y-family DNA polymerase	-
E5093_RS12470	2633880..2634167	-	288	WP_177156014.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E5093_RS12475	2634157..2634405	-	249	WP_104488392.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E5093_RS12480	2634408..2634839	-	432	WP_177156015.1	hypothetical protein	-
E5093_RS12485	2634909..2635514	-	606	WP_177156016.1	recombinase family protein	-
E5093_RS12490	2635939..2636583	+	645	WP_177156017.1	hypothetical protein	-
E5093_RS12495	2636597..2636794	+	198	WP_177156018.1	molecular chaperone DnaJ	-
E5093_RS12500	2637149..2637985	+	837	WP_177156019.1	HNH endonuclease	-
E5093_RS12505	2638306..2638701	-	396	WP_177156020.1	hypothetical protein	-
E5093_RS12510	2638914..2639177	+	264	WP_177156021.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2626219..2640515	14296

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11146.94 Da
• Isoelectric Point: 9.8659

>T123446 WP_177156014.1 NZ_CP039031:c2634167-2633880 [Acinetobacter indicus]
MTYKLDFLEEALEEWNKLNPSIKQPLKKKLVKILENPRIPKNKLSGHPDRYKIKLRSIGYRLVYEVIDDEIVVLVIAVGR
RENNAVYDDANSRHS

Nucleotide

• Length: 288 bp

>T123446 NZ_CP039031:c2634167-2633880 [Acinetobacter indicus]
ATGACCTATAAGTTAGACTTTCTAGAAGAAGCATTAGAGGAATGGAACAAGCTTAACCCAAGTATTAAGCAGCCATTGAA
GAAGAAACTGGTCAAGATTTTGGAGAATCCTAGGATTCCCAAAAATAAGCTGTCAGGACATCCTGACCGATACAAAATCA
AGCTTCGCAGTATTGGGTATCGTTTGGTTTATGAAGTGATTGATGATGAGATTGTTGTTCTAGTCATTGCTGTTGGTCGA
CGTGAAAACAATGCAGTTTATGATGATGCTAATTCCCGACACTCGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9232.69 Da
• Isoelectric Point: 5.0491

>AT123446 WP_104488392.1 NZ_CP039031:c2634405-2634157 [Acinetobacter indicus]
MTQLIHARMTASITELKKSPMDTVLAGKGEPVAILNRNTPAFYCVPADVYETMMEQLEDIELNKIADARANQKRIRVNID
DL

Nucleotide

• Length: 249 bp

>AT123446 NZ_CP039031:c2634405-2634157 [Acinetobacter indicus]
ATGACTCAACTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAGAAGAGTCCGATGGATACAGTGTTGGCAGG
TAAAGGTGAACCTGTTGCAATCCTCAATCGTAATACACCTGCGTTTTACTGTGTTCCTGCTGATGTTTATGAAACCATGA
TGGAACAGCTAGAAGACATTGAACTCAACAAAATTGCAGATGCTCGTGCGAATCAAAAACGCATTCGAGTAAATATTGAT
GACCTATAA