Detailed information of TA system TA123445

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): NpoTA/ParE(toxin)
• Location: 1590581..1591696
• Replicon: chromosome
• Accession: NZ_CP039031
• Organism: Acinetobacter indicus strain yy_1

Toxin (Protein)

• Gene name: NpoT
• Uniprot ID: V2U6R6
• Locus tag: E5093_RS07495
• Protein ID: WP_016658124.1
• Coordinates: 1591532..1591696 (+)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: NpoA
• Uniprot ID: -
• Locus tag: E5093_RS07490
• Protein ID: WP_005178053.1
• Coordinates: 1590581..1591450 (+)
• Length: 290 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5093_RS07465	1585742..1586551	-	810	WP_005178046.1	formate/nitrite transporter family protein	-
E5093_RS07470	1586845..1587294	+	450	WP_177155650.1	cyanase	-
E5093_RS07475	1587484..1587771	-	288	WP_177155651.1	KGG domain-containing protein	-
E5093_RS07480	1588333..1589574	-	1242	WP_016658127.1	MFS transporter	-
E5093_RS07485	1590235..1590474	+	240	WP_177155652.1	DUF2171 domain-containing protein	-
E5093_RS07490	1590581..1591450	+	870	WP_005178053.1	SDR family oxidoreductase	Antitoxin
E5093_RS07495	1591532..1591696	+	165	WP_016658124.1	hypothetical protein	Toxin
E5093_RS07500	1591795..1593213	-	1419	WP_177155653.1	iron-containing redox enzyme family protein	-
E5093_RS07505	1593514..1594671	-	1158	WP_171293312.1	fatty acid desaturase	-
E5093_RS07510	1594695..1595729	-	1035	WP_177155654.1	iron-sulfur cluster-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6182.76 Da
• Isoelectric Point: 10.1466

>T123445 WP_016658124.1 NZ_CP039031:1591532-1591696 [Acinetobacter indicus]
MSRGDKSAYTDKQKRQARHIIESEKERGHSEEEAERIGWSTVNKQDGGGKKKSH

Nucleotide

• Length: 165 bp

>T123445 NZ_CP039031:1591532-1591696 [Acinetobacter indicus]
ATGTCTAGAGGTGATAAGTCGGCCTATACCGACAAGCAGAAACGTCAGGCCCGCCATATTATTGAATCGGAAAAAGAGCG
AGGCCATTCCGAAGAAGAAGCAGAACGCATTGGCTGGTCTACCGTCAATAAACAGGATGGCGGCGGTAAAAAGAAATCCC
ACTAA

Antitoxin

Protein

• Length: 290 a.a.
• Molecular weight: 31879.96 Da
• Isoelectric Point: 4.8531

>AT123445 WP_005178053.1 NZ_CP039031:1590581-1591450 [Acinetobacter indicus]
MNHYPDSPSPQEKQEHQPGVQYKMTPEPEIIKSNYQGSQKLKDKVALITGGDSGIGRSVAVLFAREGANIIIPYLEEDQD
AQDTKRLVEQEGRQCLLIQCDLRQHAAVQQMVDLALQQFPHINILVNNAAVQYPQKTIEDINPEQLHKTFETNLYPLFYV
TQLLIPQMQAGDSIINTTSITSYQGHNELIDYASTKGAITAFTRSLSTNLLKNKTGIRVNGVAPGPIWTPLIPSSFDEEQ
LKGFGEDTPMGRMGQPSEVAPAYLFLASDEASYISGQVIHVNGGTIVNG

Nucleotide

• Length: 870 bp

>AT123445 NZ_CP039031:1590581-1591450 [Acinetobacter indicus]
ATGAATCATTATCCTGACAGCCCATCTCCGCAAGAGAAACAGGAGCATCAGCCTGGTGTGCAATATAAAATGACGCCCGA
ACCTGAAATTATTAAAAGCAATTATCAGGGCAGTCAAAAACTCAAAGACAAGGTGGCCTTAATTACCGGCGGTGATAGCG
GCATCGGCCGCTCCGTGGCAGTGCTGTTTGCCCGCGAAGGTGCCAATATTATTATTCCCTATTTAGAAGAAGATCAGGAT
GCGCAAGACACCAAGCGTCTAGTCGAGCAGGAAGGTCGTCAATGTCTGCTGATTCAGTGTGACCTGCGCCAGCATGCGGC
GGTACAGCAGATGGTCGATTTGGCCTTACAGCAATTTCCGCATATCAATATTCTGGTCAATAATGCCGCCGTACAATATC
CACAAAAAACCATTGAGGATATTAATCCCGAACAGTTGCATAAAACCTTTGAAACCAACCTCTACCCGCTGTTTTATGTG
ACCCAGCTGCTGATTCCTCAAATGCAGGCCGGTGACAGTATTATCAATACCACCAGTATCACCAGCTATCAGGGCCATAA
TGAGCTGATTGATTATGCCAGTACCAAAGGGGCAATTACTGCCTTTACCCGTAGCCTGTCGACCAACTTGCTGAAAAATA
AAACCGGGATTCGGGTGAATGGTGTCGCACCCGGCCCAATCTGGACGCCGTTAATTCCAAGCAGTTTTGATGAAGAACAG
CTAAAAGGTTTTGGTGAAGATACCCCCATGGGCCGCATGGGTCAGCCAAGTGAAGTTGCGCCGGCTTATCTGTTTTTAGC
CTCCGATGAAGCCAGCTATATTTCCGGTCAGGTGATTCATGTTAATGGCGGTACTATTGTCAATGGTTAA

Structures

Toxin

• AlphaFold DB: V2U6R6