Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 15841..16369 Replicon plasmid unnamed2
Accession NZ_CP039026
Organism Acinetobacter baumannii ATCC 17978 substr. PMR-High

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag E5A72_RS19335 Protein ID WP_000221358.1
Coordinates 15841..16134 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9B5Q7
Locus tag E5A72_RS19340 Protein ID WP_000246756.1
Coordinates 16124..16369 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5A72_RS19315 12615..12929 - 315 WP_061855757.1 BrnA antitoxin family protein -
E5A72_RS19320 12916..13203 - 288 WP_000438826.1 BrnT family toxin -
E5A72_RS19325 13550..14323 - 774 WP_061855758.1 glucose 1-dehydrogenase -
E5A72_RS19330 14421..15623 - 1203 WP_061855756.1 alpha/beta fold hydrolase -
E5A72_RS19335 15841..16134 - 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E5A72_RS19340 16124..16369 - 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E5A72_RS19345 16613..16816 + 204 WP_000482656.1 hypothetical protein -
E5A72_RS19545 17001..17144 - 144 WP_001125244.1 hypothetical protein -
E5A72_RS19350 17164..17739 - 576 WP_001096616.1 helix-turn-helix domain-containing protein -
E5A72_RS19355 17732..18682 - 951 WP_001205343.1 replication initiation protein RepM -
E5A72_RS19370 19891..20262 + 372 WP_000504218.1 hypothetical protein -
E5A72_RS19375 20262..20459 + 198 WP_001282483.1 hypothetical protein -
E5A72_RS19380 20581..21279 - 699 WP_000007662.1 CPBP family intramembrane metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..30410 30410


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T123443 WP_000221358.1 NZ_CP039026:c16134-15841 [Acinetobacter baumannii ATCC 17978]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T123443 NZ_CP039026:c16134-15841 [Acinetobacter baumannii ATCC 17978]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGGGATCAATTTAA
GAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTGAGAGGCGATCTTGCAGGTTGCTATAAAA
TTAAATTATTAAAAGCTGGTGTCAGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCTTGCTCATCACAGTCGGG
AAACGAGCTGATAGCATAGTTTATGACGAAGCTAAAAAGCGCATTAAAGACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9235.61 Da        Isoelectric Point: 4.3142

>AT123443 WP_000246756.1 NZ_CP039026:c16369-16124 [Acinetobacter baumannii ATCC 17978]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT123443 NZ_CP039026:c16369-16124 [Acinetobacter baumannii ATCC 17978]
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCCTATTCCATCCTTAAAGAACAAGGTATTGCACC
TACAGATTTCTTTACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTACCTGTCAAAAAAGCTTTGCTTTCAGAAG
AAGATGAAGAATTGTTAGCTCTTGTCCGTAAGCGCATTAATGACCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB N9B5Q7

References