123441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 1346..1934 Replicon plasmid unnamed2
Accession NZ_CP039026
Organism Acinetobacter baumannii ATCC 17978 substr. PMR-High

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag E5A72_RS19245 Protein ID WP_000438826.1
Coordinates 1647..1934 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A858UV00
Locus tag E5A72_RS19240 Protein ID WP_061855757.1
Coordinates 1346..1660 (-) Length 105 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5A72_RS19235 1..1220 - 1220 Protein_0 TonB-dependent receptor ZnuD2 -
E5A72_RS19240 1346..1660 - 315 WP_061855757.1 BrnA antitoxin family protein Antitoxin
E5A72_RS19245 1647..1934 - 288 WP_000438826.1 BrnT family toxin Toxin
E5A72_RS19250 2282..3034 - 753 Protein_3 SDR family oxidoreductase -
E5A72_RS19255 3167..4328 - 1162 Protein_4 alpha/beta fold hydrolase -
E5A72_RS19260 4546..4838 - 293 Protein_5 type II toxin-antitoxin system RelE/ParE family toxin -
E5A72_RS19265 4828..5072 - 245 Protein_6 type II toxin-antitoxin system RelB/DinJ family antitoxin -
E5A72_RS19270 5316..5519 + 204 WP_000482656.1 hypothetical protein -
E5A72_RS19540 5703..5846 - 144 WP_001125244.1 hypothetical protein -
E5A72_RS19275 5866..6440 - 575 Protein_9 helix-turn-helix domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..30410 30410


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T123441 WP_000438826.1 NZ_CP039026:c1934-1647 [Acinetobacter baumannii ATCC 17978]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T123441 NZ_CP039026:c1934-1647 [Acinetobacter baumannii ATCC 17978]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12227.88 Da        Isoelectric Point: 8.4628

>AT123441 WP_061855757.1 NZ_CP039026:c1660-1346 [Acinetobacter baumannii ATCC 17978]
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT123441 NZ_CP039026:c1660-1346 [Acinetobacter baumannii ATCC 17978]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTAAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6


Antitoxin

Source ID Structure
AlphaFold DB A0A858UV00

References