Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 925446..926099 Replicon chromosome
Accession NZ_CP039025
Organism Acinetobacter baumannii ATCC 17978 substr. PMR-High

Toxin (Protein)


Gene name cptA Uniprot ID A0A1E3M967
Locus tag E5A72_RS04465 Protein ID WP_009518132.1
Coordinates 925446..925835 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag E5A72_RS04470 Protein ID WP_001288210.1
Coordinates 925842..926099 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5A72_RS04450 920563..922758 - 2196 WP_001158904.1 TRAP transporter large permease subunit -
E5A72_RS04455 922946..923512 - 567 WP_000651535.1 rhombosortase -
E5A72_RS04460 923591..924676 - 1086 WP_000049106.1 hypothetical protein -
E5A72_RS04465 925446..925835 - 390 WP_009518132.1 hypothetical protein Toxin
E5A72_RS04470 925842..926099 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
E5A72_RS04475 926287..927459 + 1173 WP_001190550.1 acyl-CoA dehydrogenase family protein -
E5A72_RS04480 927509..928999 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
E5A72_RS04485 929181..929558 - 378 WP_001216380.1 50S ribosomal protein L17 -
E5A72_RS04490 929577..930584 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15720.03 Da        Isoelectric Point: 10.4623

>T123438 WP_009518132.1 NZ_CP039025:c925835-925446 [Acinetobacter baumannii ATCC 17978]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFINFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLTEWKKLKTLEKLY

Download         Length: 390 bp

>T123438 NZ_CP039025:c925835-925446 [Acinetobacter baumannii ATCC 17978]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAACTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCATTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAACAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT123438 WP_001288210.1 NZ_CP039025:c926099-925842 [Acinetobacter baumannii ATCC 17978]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT123438 NZ_CP039025:c926099-925842 [Acinetobacter baumannii ATCC 17978]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3M967

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References