Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 201824..202353 Replicon chromosome
Accession NZ_CP038996
Organism Enterococcus faecium strain SRR24

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag E6A31_RS00985 Protein ID WP_002296560.1
Coordinates 202087..202353 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag E6A31_RS00980 Protein ID WP_002296559.1
Coordinates 201824..202087 (+) Length 88 a.a.

Genomic Context


E6A31_RS00965E6A31_RS00980E6A31_RS00985E6A31_RS00990E6A31_RS01015E6A31_RS00970E6A31_RS00995E6A31_RS01000E6A31_RS01005E6A31_RS01010
Location: 199198..201021 (1824 bp)
Type: Others
Protein ID: WP_002294202.1
Location: 201824..202087 (264 bp)
Type: Antitoxin
Protein ID: WP_002296559.1
Location: 202087..202353 (267 bp)
Type: Toxin
Protein ID: WP_002296560.1
Location: 202554..203042 (489 bp)
Type: Others
Protein ID: WP_002296561.1
Location: 206549..206953 (405 bp)
Type: Others
Protein ID: WP_002287522.1
Location: 201163..201348 (186 bp)
Type: Others
Protein ID: WP_002296558.1
Location: 203583..204254 (672 bp)
Type: Others
Protein ID: WP_002302663.1
Location: 204251..205168 (918 bp)
Type: Others
Protein ID: WP_002296564.1
Location: 205165..205806 (642 bp)
Type: Others
Protein ID: WP_002293405.1
Location: 205810..206391 (582 bp)
Type: Others
Protein ID: Protein_201
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
E6A31_RS00965199198..201021+1824WP_002294202.1APC family permease-
E6A31_RS00970201163..201348-186WP_002296558.1transcriptional regulator-
E6A31_RS00980201824..202087+264WP_002296559.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
E6A31_RS00985202087..202353+267WP_002296560.1Txe/YoeB family addiction module toxinToxin
E6A31_RS00990202554..203042+489WP_002296561.1mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-
E6A31_RS00995203583..204254-672WP_002302663.1ABC transporter permease-
E6A31_RS01000204251..205168-918WP_002296564.1osmoprotectant ABC transporter substrate-binding protein-
E6A31_RS01005205165..205806-642WP_002293405.1ABC transporter permease-
E6A31_RS01010205810..206391-582Protein_201CBS domain-containing protein-
E6A31_RS01015206549..206953+405WP_002287522.1IS200/IS605-like element ISEfa4 family transposase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-87)

Antitoxin

(5-69)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T123431 WP_002296560.1 NZ_CP038996:202087-202353 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T123431 NZ_CP038996:202087-202353 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT123431 WP_002296559.1 NZ_CP038996:201824-202087 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT123431 NZ_CP038996:201824-202087 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A829FCW8


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A829F3T0

References