Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-yefM/Txe-RelB |
Location | 201824..202353 | Replicon | chromosome |
Accession | NZ_CP038996 | ||
Organism | Enterococcus faecium strain SRR24 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q3XX67 |
Locus tag | E6A31_RS00985 | Protein ID | WP_002296560.1 |
Coordinates | 202087..202353 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A829F3T0 |
Locus tag | E6A31_RS00980 | Protein ID | WP_002296559.1 |
Coordinates | 201824..202087 (+) | Length | 88 a.a. |
Genomic Context
Location: 199198..201021 (1824 bp)
Type: Others
Protein ID: WP_002294202.1
Type: Others
Protein ID: WP_002294202.1
Location: 201824..202087 (264 bp)
Type: Antitoxin
Protein ID: WP_002296559.1
Type: Antitoxin
Protein ID: WP_002296559.1
Location: 202087..202353 (267 bp)
Type: Toxin
Protein ID: WP_002296560.1
Type: Toxin
Protein ID: WP_002296560.1
Location: 202554..203042 (489 bp)
Type: Others
Protein ID: WP_002296561.1
Type: Others
Protein ID: WP_002296561.1
Location: 206549..206953 (405 bp)
Type: Others
Protein ID: WP_002287522.1
Type: Others
Protein ID: WP_002287522.1
Location: 201163..201348 (186 bp)
Type: Others
Protein ID: WP_002296558.1
Type: Others
Protein ID: WP_002296558.1
Location: 203583..204254 (672 bp)
Type: Others
Protein ID: WP_002302663.1
Type: Others
Protein ID: WP_002302663.1
Location: 204251..205168 (918 bp)
Type: Others
Protein ID: WP_002296564.1
Type: Others
Protein ID: WP_002296564.1
Location: 205165..205806 (642 bp)
Type: Others
Protein ID: WP_002293405.1
Type: Others
Protein ID: WP_002293405.1
Location: 205810..206391 (582 bp)
Type: Others
Protein ID: Protein_201
Type: Others
Protein ID: Protein_201
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E6A31_RS00965 | 199198..201021 | + | 1824 | WP_002294202.1 | APC family permease | - |
E6A31_RS00970 | 201163..201348 | - | 186 | WP_002296558.1 | transcriptional regulator | - |
E6A31_RS00980 | 201824..202087 | + | 264 | WP_002296559.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
E6A31_RS00985 | 202087..202353 | + | 267 | WP_002296560.1 | Txe/YoeB family addiction module toxin | Toxin |
E6A31_RS00990 | 202554..203042 | + | 489 | WP_002296561.1 | mannosyl-glycoprotein endo-beta-N-acetylglucosamidase | - |
E6A31_RS00995 | 203583..204254 | - | 672 | WP_002302663.1 | ABC transporter permease | - |
E6A31_RS01000 | 204251..205168 | - | 918 | WP_002296564.1 | osmoprotectant ABC transporter substrate-binding protein | - |
E6A31_RS01005 | 205165..205806 | - | 642 | WP_002293405.1 | ABC transporter permease | - |
E6A31_RS01010 | 205810..206391 | - | 582 | Protein_201 | CBS domain-containing protein | - |
E6A31_RS01015 | 206549..206953 | + | 405 | WP_002287522.1 | IS200/IS605-like element ISEfa4 family transposase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10660.13 Da Isoelectric Point: 9.9931
>T123431 WP_002296560.1 NZ_CP038996:202087-202353 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
Download Length: 267 bp
>T123431 NZ_CP038996:202087-202353 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10046.05 Da Isoelectric Point: 4.1207
>AT123431 WP_002296559.1 NZ_CP038996:201824-202087 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL
Download Length: 264 bp
>AT123431 NZ_CP038996:201824-202087 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829FCW8 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F3T0 |