Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 57526..58096 Replicon plasmid unnamed1
Accession NZ_CP038973
Organism Piscirickettsia salmonis strain Psal-069

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Psal069_RS16710 Protein ID WP_129556708.1
Coordinates 57526..57861 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Psal069_RS16715 Protein ID WP_016212365.1
Coordinates 57854..58096 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal069_RS16675 53202..53579 + 378 Protein_72 DDE-type integrase/transposase/recombinase -
Psal069_RS16680 53680..54459 + 780 WP_081377351.1 transposase -
Psal069_RS16690 54648..54980 + 333 WP_032126739.1 transposase -
Psal069_RS16695 55145..55522 + 378 WP_016212154.1 DDE-type integrase/transposase/recombinase -
Psal069_RS16700 55829..56212 - 384 WP_016212152.1 hypothetical protein -
Psal069_RS16705 56682..57410 - 729 WP_054300202.1 IS6 family transposase -
Psal069_RS16710 57526..57861 - 336 WP_129556708.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Psal069_RS16715 57854..58096 - 243 WP_016212365.1 antidote-toxin recognition MazE family protein Antitoxin
Psal069_RS16720 58305..59279 + 975 WP_054300271.1 IS30 family transposase -
Psal069_RS16725 59407..59847 + 441 Protein_81 tyrosine-type recombinase/integrase -
Psal069_RS16730 59915..60643 + 729 WP_075275142.1 IS6 family transposase -
Psal069_RS16735 60926..62611 + 1686 WP_075275141.1 protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..158592 158592
- inside IScluster/Tn - - 30827..64351 33524


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12345.36 Da        Isoelectric Point: 10.3188

>T123411 WP_129556708.1 NZ_CP038973:c57861-57526 [Piscirickettsia salmonis]
MNKVPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKPYNLKVGLVTGCPVTSKIKGYPFEVEIPKNNSVHGAVLVNQLTTK
DFRARGWNHADKLDKKSLERVQGLIDVMLKG

Download         Length: 336 bp

>T123411 NZ_CP038973:c57861-57526 [Piscirickettsia salmonis]
TTGAATAAAGTGCCTGAACGTGGTGATATTATTTTTCTTAGTTTAGACCCTACATTAGGTAGTGAACAAAGAGGAAACCG
ACCCTTTTTAGTGTTGACTTCCAAGCCCTATAACTTAAAGGTGGGACTTGTGACGGGGTGCCCGGTTACTTCAAAGATTA
AAGGATATCCTTTTGAAGTTGAGATACCTAAAAACAATAGCGTTCACGGAGCAGTGTTGGTTAACCAACTAACAACAAAA
GATTTCCGTGCTAGGGGCTGGAATCATGCTGATAAGCTCGATAAAAAATCTCTTGAAAGAGTTCAGGGGCTAATTGATGT
GATGTTGAAAGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.09 Da        Isoelectric Point: 4.4750

>AT123411 WP_016212365.1 NZ_CP038973:c58096-57854 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTIDKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEELGGERFE

Download         Length: 243 bp

>AT123411 NZ_CP038973:c58096-57854 [Piscirickettsia salmonis]
ATGGATGCAGTTGTTAGAAAATGGGGGAATAGCTTGGGGTTGTTGCTACCCTTGAGCATCGCACGTGAACTTCATATCAA
TGATGGTAGTCATGTGACGATTGATAAGGTCGGGGATGAGATTCACATTAAACCTTTGACTCATACGCAGACCCTTGAAT
TATTATTATCAGAAATTACCCCTGAAAATAGTCATGATTTAGTAGATTGGGGTGAAGAATTAGGAGGGGAGCGCTTTGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References