Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 32511..33069 Replicon plasmid unnamed3
Accession NZ_CP038960
Organism Piscirickettsia salmonis strain Psal-041

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag Psal041_RS17855 Protein ID WP_155047328.1
Coordinates 32857..33069 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag Psal041_RS17850 Protein ID WP_155047327.1
Coordinates 32511..32864 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal041_RS17825 28057..28356 - 300 WP_016210976.1 hypothetical protein -
Psal041_RS17830 28510..28815 - 306 WP_016210958.1 hypothetical protein -
Psal041_RS18460 29075..29227 - 153 WP_162034504.1 hypothetical protein -
Psal041_RS17835 29484..30239 + 756 WP_016210971.1 methyltransferase domain-containing protein -
Psal041_RS17840 30274..31041 + 768 WP_075275197.1 ester cyclase -
Psal041_RS17845 31062..32441 - 1380 WP_155047326.1 MFS transporter -
Psal041_RS17850 32511..32864 - 354 WP_155047327.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Psal041_RS17855 32857..33069 - 213 WP_155047328.1 type II toxin-antitoxin system HicA family toxin Toxin
Psal041_RS17860 33113..34087 - 975 WP_054300271.1 IS30 family transposase -
Psal041_RS17865 34447..34776 - 330 WP_155047329.1 hypothetical protein -
Psal041_RS17870 35234..35473 + 240 WP_080963666.1 transposase zinc-binding domain-containing protein -
Psal041_RS17875 35398..36360 + 963 WP_036773142.1 IS91 family transposase -
Psal041_RS17880 36686..37732 + 1047 WP_027243195.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..38426 38426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(7-66)

Antitoxin

Uncharacterised protein family HicB

(53-103)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7691.99 Da        Isoelectric Point: 10.5676

>T123402 WP_155047328.1 NZ_CP038960:c33069-32857 [Piscirickettsia salmonis]
IKASIVWADIEKLLLALGAEVIERDGSRVAVILNQVKTTFHRPHPEKTTDKGAVKSIRLFLKNAGVDKNA

Download         Length: 213 bp

>T123402 NZ_CP038960:c33069-32857 [Piscirickettsia salmonis]
ATCAAAGCAAGCATTGTTTGGGCTGATATAGAAAAGCTTCTTTTAGCGTTAGGGGCTGAAGTAATAGAGCGTGATGGTTC
AAGGGTTGCTGTCATTTTGAATCAAGTGAAAACAACATTTCATAGACCGCACCCTGAAAAAACAACAGACAAGGGGGCGG
TTAAGTCAATAAGGTTGTTTTTAAAAAATGCTGGAGTAGATAAAAATGCTTAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13476.43 Da        Isoelectric Point: 5.0200

>AT123402 WP_155047327.1 NZ_CP038960:c32864-32511 [Piscirickettsia salmonis]
MLKYKGYIGKVEEIHEGDEYIYGIVPNIKDVISFKGKNIKELTKDFKLAIDDYLALCDEREEEPDKPFSGRFMTRLGSDL
HEEVFLASMNDSGAKSMNDWVVSACLEKLKHDQIVKR

Download         Length: 354 bp

>AT123402 NZ_CP038960:c32864-32511 [Piscirickettsia salmonis]
ATGCTTAAATACAAAGGTTATATTGGAAAAGTTGAAGAGATTCATGAAGGTGATGAATATATTTATGGGATTGTTCCAAA
TATTAAAGATGTTATTTCTTTTAAAGGTAAAAATATAAAAGAGTTAACGAAAGACTTTAAGCTGGCTATTGATGATTATT
TGGCTTTATGTGATGAGCGTGAAGAAGAACCCGATAAACCATTTTCTGGTAGATTTATGACTAGATTAGGTAGTGATTTG
CATGAAGAGGTTTTTTTAGCTTCTATGAATGATTCAGGTGCAAAATCAATGAATGATTGGGTTGTATCTGCATGCTTGGA
AAAGTTGAAGCATGATCAAATCGTTAAACGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References