Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 131311..131881 Replicon plasmid unnamed1
Accession NZ_CP038958
Organism Piscirickettsia salmonis strain Psal-041

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Psal041_RS17105 Protein ID WP_036781349.1
Coordinates 131555..131881 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Psal041_RS17100 Protein ID WP_016212365.1
Coordinates 131311..131553 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal041_RS18430 127152..127883 - 732 WP_016212311.1 hypothetical protein -
Psal041_RS17085 128004..129587 - 1584 WP_052047129.1 protein kinase -
Psal041_RS17090 129870..130598 - 729 WP_075274745.1 IS6-like element ISPsa2 family transposase -
Psal041_RS17095 130666..131106 - 441 Protein_173 tyrosine-type recombinase/integrase -
Psal041_RS17100 131311..131553 + 243 WP_016212365.1 antidote-toxin recognition MazE family protein Antitoxin
Psal041_RS17105 131555..131881 + 327 WP_036781349.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Psal041_RS17110 131997..132725 + 729 WP_054300202.1 IS6 family transposase -
Psal041_RS17115 133195..133578 + 384 WP_016212152.1 hypothetical protein -
Psal041_RS17120 133885..134262 - 378 WP_016212154.1 DDE-type integrase/transposase/recombinase -
Psal041_RS17125 134427..134759 - 333 WP_155047283.1 transposase -
Psal041_RS17135 134948..135727 - 780 WP_081377351.1 transposase -
Psal041_RS17140 135828..136085 - 258 Protein_181 DDE-type integrase/transposase/recombinase -
Psal041_RS18435 136374..136493 - 120 Protein_182 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..149109 149109
- inside IScluster/Tn - - 126264..143539 17275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-104)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11971.89 Da        Isoelectric Point: 10.1733

>T123400 WP_036781349.1 NZ_CP038958:131555-131881 [Piscirickettsia salmonis]
VPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKPYNLKVGLVTGCPVTSKIKGYPFEVELPKNNSVHGAVLVNQLTTKDFR
ARGWNHADKLDKKSLERVQGLIDVMLKG

Download         Length: 327 bp

>T123400 NZ_CP038958:131555-131881 [Piscirickettsia salmonis]
GTGCCTGAACGTGGTGATATTATTTTTCTTAGTTTAGACCCTACATTAGGTAGTGAACAAAGAGGAAACCGACCCTTTTT
AGTGTTGACTTCCAAGCCCTATAACTTAAAGGTGGGACTTGTGACGGGGTGCCCGGTTACTTCAAAGATTAAAGGATATC
CTTTTGAAGTTGAGCTACCTAAAAACAATAGCGTTCACGGAGCAGTGTTGGTTAACCAACTAACAACAAAAGATTTCCGT
GCTAGGGGCTGGAATCATGCTGATAAGCTCGATAAAAAATCTCTTGAAAGAGTTCAGGGGCTAATTGATGTGATGTTGAA
AGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.09 Da        Isoelectric Point: 4.4750

>AT123400 WP_016212365.1 NZ_CP038958:131311-131553 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTIDKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEELGGERFE

Download         Length: 243 bp

>AT123400 NZ_CP038958:131311-131553 [Piscirickettsia salmonis]
ATGGATGCAGTTGTTAGAAAATGGGGGAATAGCTTGGGGTTGTTGCTACCCTTGAGCATCGCACGTGAACTTCATATCAA
TGATGGTAGTCATGTGACGATTGATAAGGTCGGGGATGAGATTCACATTAAACCTTTGACTCATACGCAGACCCTTGAAT
TATTATTATCAGAAATTACCCCTGAAAATAGTCATGATTTAGTAGATTGGGGTGAAGAATTAGGAGGGGAGCGCTTTGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References