Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 171210..171780 Replicon plasmid unnamed1
Accession NZ_CP038948
Organism Piscirickettsia salmonis strain Psal-028

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Psal028_RS17360 Protein ID WP_036781349.1
Coordinates 171454..171780 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Psal028_RS17355 Protein ID WP_016212365.1
Coordinates 171210..171452 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal028_RS17330 167051..167782 - 732 WP_016212311.1 hypothetical protein -
Psal028_RS17340 167903..169486 - 1584 WP_052047129.1 protein kinase -
Psal028_RS17345 169769..170497 - 729 WP_075274745.1 IS6-like element ISPsa2 family transposase -
Psal028_RS17350 170565..171005 - 441 Protein_222 tyrosine-type recombinase/integrase -
Psal028_RS17355 171210..171452 + 243 WP_016212365.1 antidote-toxin recognition MazE family protein Antitoxin
Psal028_RS17360 171454..171780 + 327 WP_036781349.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Psal028_RS17365 171896..172624 + 729 WP_054300202.1 IS6 family transposase -
Psal028_RS17370 173094..173477 + 384 WP_016212152.1 hypothetical protein -
Psal028_RS17375 173784..174161 - 378 WP_016212154.1 DDE-type integrase/transposase/recombinase -
Psal028_RS17380 174326..174658 - 333 WP_155047283.1 transposase -
Psal028_RS17390 174847..175626 - 780 WP_081377351.1 transposase -
Psal028_RS17395 175727..175984 - 258 Protein_230 DDE-type integrase/transposase/recombinase -
Psal028_RS18645 176273..176392 - 120 Protein_231 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..189008 189008
- inside IScluster/Tn - - 166163..183438 17275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-104)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11971.89 Da        Isoelectric Point: 10.1733

>T123392 WP_036781349.1 NZ_CP038948:171454-171780 [Piscirickettsia salmonis]
VPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKPYNLKVGLVTGCPVTSKIKGYPFEVELPKNNSVHGAVLVNQLTTKDFR
ARGWNHADKLDKKSLERVQGLIDVMLKG

Download         Length: 327 bp

>T123392 NZ_CP038948:171454-171780 [Piscirickettsia salmonis]
GTGCCTGAACGTGGTGATATTATTTTTCTTAGTTTAGACCCTACATTAGGTAGTGAACAAAGAGGAAACCGACCCTTTTT
AGTGTTGACTTCCAAGCCCTATAACTTAAAGGTGGGACTTGTGACGGGGTGCCCGGTTACTTCAAAGATTAAAGGATATC
CTTTTGAAGTTGAGCTACCTAAAAACAATAGCGTTCACGGAGCAGTGTTGGTTAACCAACTAACAACAAAAGATTTCCGT
GCTAGGGGCTGGAATCATGCTGATAAGCTCGATAAAAAATCTCTTGAAAGAGTTCAGGGGCTAATTGATGTGATGTTGAA
AGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.09 Da        Isoelectric Point: 4.4750

>AT123392 WP_016212365.1 NZ_CP038948:171210-171452 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTIDKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEELGGERFE

Download         Length: 243 bp

>AT123392 NZ_CP038948:171210-171452 [Piscirickettsia salmonis]
ATGGATGCAGTTGTTAGAAAATGGGGGAATAGCTTGGGGTTGTTGCTACCCTTGAGCATCGCACGTGAACTTCATATCAA
TGATGGTAGTCATGTGACGATTGATAAGGTCGGGGATGAGATTCACATTAAACCTTTGACTCATACGCAGACCCTTGAAT
TATTATTATCAGAAATTACCCCTGAAAATAGTCATGATTTAGTAGATTGGGGTGAAGAATTAGGAGGGGAGCGCTTTGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References