Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 97905..98475 Replicon plasmid unnamed1
Accession NZ_CP038933
Organism Piscirickettsia salmonis strain Psal-025

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Psal025_RS16965 Protein ID WP_129556708.1
Coordinates 97905..98240 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Psal025_RS16970 Protein ID WP_016212365.1
Coordinates 98233..98475 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal025_RS16930 93581..93958 + 378 Protein_111 DDE-type integrase/transposase/recombinase -
Psal025_RS16935 94059..94838 + 780 WP_081377351.1 transposase -
Psal025_RS16945 95027..95359 + 333 WP_032126739.1 transposase -
Psal025_RS16950 95524..95901 + 378 WP_016212154.1 DDE-type integrase/transposase/recombinase -
Psal025_RS16955 96208..96591 - 384 WP_016212152.1 hypothetical protein -
Psal025_RS16960 97061..97789 - 729 WP_054300202.1 IS6 family transposase -
Psal025_RS16965 97905..98240 - 336 WP_129556708.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Psal025_RS16970 98233..98475 - 243 WP_016212365.1 antidote-toxin recognition MazE family protein Antitoxin
Psal025_RS16975 98684..99658 + 975 WP_054300271.1 IS30 family transposase -
Psal025_RS16980 99786..100226 + 441 Protein_120 tyrosine-type recombinase/integrase -
Psal025_RS16985 100294..101022 + 729 WP_075275142.1 IS6 family transposase -
Psal025_RS16990 101305..102990 + 1686 WP_075275141.1 protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..225323 225323
- inside IScluster/Tn - - 89887..104730 14843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12345.36 Da        Isoelectric Point: 10.3188

>T123380 WP_129556708.1 NZ_CP038933:c98240-97905 [Piscirickettsia salmonis]
MNKVPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKPYNLKVGLVTGCPVTSKIKGYPFEVEIPKNNSVHGAVLVNQLTTK
DFRARGWNHADKLDKKSLERVQGLIDVMLKG

Download         Length: 336 bp

>T123380 NZ_CP038933:c98240-97905 [Piscirickettsia salmonis]
TTGAATAAAGTGCCTGAACGTGGTGATATTATTTTTCTTAGTTTAGACCCTACATTAGGTAGTGAACAAAGAGGAAACCG
ACCCTTTTTAGTGTTGACTTCCAAGCCCTATAACTTAAAGGTGGGACTTGTGACGGGGTGCCCGGTTACTTCAAAGATTA
AAGGATATCCTTTTGAAGTTGAGATACCTAAAAACAATAGCGTTCACGGAGCAGTGTTGGTTAACCAACTAACAACAAAA
GATTTCCGTGCTAGGGGCTGGAATCATGCTGATAAGCTCGATAAAAAATCTCTTGAAAGAGTTCAGGGGCTAATTGATGT
GATGTTGAAAGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.09 Da        Isoelectric Point: 4.4750

>AT123380 WP_016212365.1 NZ_CP038933:c98475-98233 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTIDKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEELGGERFE

Download         Length: 243 bp

>AT123380 NZ_CP038933:c98475-98233 [Piscirickettsia salmonis]
ATGGATGCAGTTGTTAGAAAATGGGGGAATAGCTTGGGGTTGTTGCTACCCTTGAGCATCGCACGTGAACTTCATATCAA
TGATGGTAGTCATGTGACGATTGATAAGGTCGGGGATGAGATTCACATTAAACCTTTGACTCATACGCAGACCCTTGAAT
TATTATTATCAGAAATTACCCCTGAAAATAGTCATGATTTAGTAGATTGGGGTGAAGAATTAGGAGGGGAGCGCTTTGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References