Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 43457..44100 Replicon plasmid unnamed1
Accession NZ_CP038928
Organism Piscirickettsia salmonis strain Psal-013

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L6TI66
Locus tag Psal013_RS16645 Protein ID WP_027242931.1
Coordinates 43457..43864 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L6TI10
Locus tag Psal013_RS16650 Protein ID WP_027242932.1
Coordinates 43873..44100 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal013_RS16620 39054..40385 - 1332 WP_048876205.1 terminase large subunit -
Psal013_RS16625 40388..40870 - 483 WP_075278733.1 P27 family phage terminase small subunit -
Psal013_RS16630 40957..41340 - 384 WP_027242929.1 HNH endonuclease -
Psal013_RS16635 41536..41739 - 204 WP_017375952.1 hypothetical protein -
Psal013_RS16640 41929..43311 - 1383 WP_027242930.1 hypothetical protein -
Psal013_RS16645 43457..43864 - 408 WP_027242931.1 DUF4411 family protein Toxin
Psal013_RS16650 43873..44100 - 228 WP_027242932.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Psal013_RS16655 44233..44598 - 366 WP_026063496.1 hypothetical protein -
Psal013_RS16660 45477..45806 - 330 WP_162038692.1 HigA family addiction module antidote protein -
Psal013_RS16665 45872..46021 + 150 WP_196214251.1 hypothetical protein -
Psal013_RS16670 46159..46392 - 234 WP_017375959.1 type II toxin-antitoxin system RelE/ParE family toxin -
Psal013_RS16675 46694..47737 + 1044 WP_017375960.1 NAD(P)-dependent alcohol dehydrogenase -
Psal013_RS16680 47845..48252 + 408 WP_036817201.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..159159 159159


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(7-41)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15562.93 Da        Isoelectric Point: 7.4168

>T123376 WP_027242931.1 NZ_CP038928:c43864-43457 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLDVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVDHLELEDWAS

Download         Length: 408 bp

>T123376 NZ_CP038928:c43864-43457 [Piscirickettsia salmonis]
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAACCTCGCTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCGATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGCAGTCAAC
ACCAGCGAAAAAATCAGGAAGCAATTAATACCTTGGTGAATAAGCTCGATGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCACATGC
GCTTTCAGAAAAGGCTGTTTTAGTAACGCATAATACAAAAGAGTTTCAGCGTGTCGATCATTTAGAGCTTGAAGACTGGG
CAAGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8948.07 Da        Isoelectric Point: 4.5700

>AT123376 WP_027242932.1 NZ_CP038928:c44100-43873 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDRQDIQAQERDWF

Download         Length: 228 bp

>AT123376 NZ_CP038928:c44100-43873 [Piscirickettsia salmonis]
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCTCAAGCCGTTCGATTACCGAAAGAAATGCGCCTTGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCATATGC
CGGATGTATCGGATGATTTTATGGAGGATCGCCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TI66

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI10

References