Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 23117..23648 Replicon plasmid unnamed1
Accession NZ_CP038928
Organism Piscirickettsia salmonis strain Psal-013

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag Psal013_RS16515 Protein ID WP_027243212.1
Coordinates 23117..23404 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag Psal013_RS16520 Protein ID WP_027243211.1
Coordinates 23394..23648 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal013_RS16485 19040..19501 - 462 WP_155049765.1 transposase -
Psal013_RS16490 19609..20100 - 492 WP_069971704.1 DUF1561 family protein -
Psal013_RS16495 20182..21159 + 978 WP_036771347.1 IS5 family transposase -
Psal013_RS16500 21174..21791 + 618 WP_155049766.1 IS5 family transposase -
Psal013_RS16505 21795..22622 + 828 WP_069971703.1 IS5 family transposase -
Psal013_RS16510 22649..23110 + 462 Protein_29 tail assembly protein -
Psal013_RS16515 23117..23404 - 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Psal013_RS16520 23394..23648 - 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Psal013_RS16525 23866..24027 - 162 WP_155046636.1 hypothetical protein -
Psal013_RS16530 24042..25019 - 978 WP_036771347.1 IS5 family transposase -
Psal013_RS16535 25038..25271 - 234 WP_062365770.1 hypothetical protein -
Psal013_RS16540 25353..26330 + 978 WP_036771347.1 IS5 family transposase -
Psal013_RS16545 26370..26714 + 345 Protein_36 DDE-type integrase/transposase/recombinase -
Psal013_RS16550 26796..27776 - 981 WP_144420849.1 hypothetical protein -
Psal013_RS16555 28008..28517 - 510 WP_027242595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..159159 159159


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T123375 WP_027243212.1 NZ_CP038928:c23404-23117 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T123375 NZ_CP038928:c23404-23117 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT123375 WP_027243211.1 NZ_CP038928:c23648-23394 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT123375 NZ_CP038928:c23648-23394 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References