Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 57238..57808 Replicon plasmid unnamed1
Accession NZ_CP038924
Organism Piscirickettsia salmonis strain Psal-011

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Psal011_RS16760 Protein ID WP_129556708.1
Coordinates 57238..57573 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Psal011_RS16765 Protein ID WP_016212365.1
Coordinates 57566..57808 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal011_RS16725 52914..53291 + 378 Protein_70 DDE-type integrase/transposase/recombinase -
Psal011_RS16730 53392..54171 + 780 WP_081377351.1 transposase -
Psal011_RS16740 54360..54692 + 333 WP_032126739.1 transposase -
Psal011_RS16745 54857..55234 + 378 WP_016212154.1 DDE-type integrase/transposase/recombinase -
Psal011_RS16750 55541..55924 - 384 WP_016212152.1 hypothetical protein -
Psal011_RS16755 56394..57122 - 729 WP_054300202.1 IS6 family transposase -
Psal011_RS16760 57238..57573 - 336 WP_129556708.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Psal011_RS16765 57566..57808 - 243 WP_016212365.1 antidote-toxin recognition MazE family protein Antitoxin
Psal011_RS16770 58017..58991 + 975 WP_054300271.1 IS30 family transposase -
Psal011_RS16775 59119..59559 + 441 Protein_79 tyrosine-type recombinase/integrase -
Psal011_RS16780 59627..60355 + 729 WP_075275142.1 IS6 family transposase -
Psal011_RS16785 60638..62323 + 1686 WP_075275141.1 protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..158304 158304
- inside IScluster/Tn - - 30827..64063 33236


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12345.36 Da        Isoelectric Point: 10.3188

>T123370 WP_129556708.1 NZ_CP038924:c57573-57238 [Piscirickettsia salmonis]
MNKVPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKPYNLKVGLVTGCPVTSKIKGYPFEVEIPKNNSVHGAVLVNQLTTK
DFRARGWNHADKLDKKSLERVQGLIDVMLKG

Download         Length: 336 bp

>T123370 NZ_CP038924:c57573-57238 [Piscirickettsia salmonis]
TTGAATAAAGTGCCTGAACGTGGTGATATTATTTTTCTTAGTTTAGACCCTACATTAGGTAGTGAACAAAGAGGAAACCG
ACCCTTTTTAGTGTTGACTTCCAAGCCCTATAACTTAAAGGTGGGACTTGTGACGGGGTGCCCGGTTACTTCAAAGATTA
AAGGATATCCTTTTGAAGTTGAGATACCTAAAAACAATAGCGTTCACGGAGCAGTGTTGGTTAACCAACTAACAACAAAA
GATTTCCGTGCTAGGGGCTGGAATCATGCTGATAAGCTCGATAAAAAATCTCTTGAAAGAGTTCAGGGGCTAATTGATGT
GATGTTGAAAGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.09 Da        Isoelectric Point: 4.4750

>AT123370 WP_016212365.1 NZ_CP038924:c57808-57566 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTIDKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEELGGERFE

Download         Length: 243 bp

>AT123370 NZ_CP038924:c57808-57566 [Piscirickettsia salmonis]
ATGGATGCAGTTGTTAGAAAATGGGGGAATAGCTTGGGGTTGTTGCTACCCTTGAGCATCGCACGTGAACTTCATATCAA
TGATGGTAGTCATGTGACGATTGATAAGGTCGGGGATGAGATTCACATTAAACCTTTGACTCATACGCAGACCCTTGAAT
TATTATTATCAGAAATTACCCCTGAAAATAGTCATGATTTAGTAGATTGGGGTGAAGAATTAGGAGGGGAGCGCTTTGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References