Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 345265..345835 Replicon chromosome
Accession NZ_CP038908
Organism Piscirickettsia salmonis strain Psal-009

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Psal009_RS01790 Protein ID WP_036781349.1
Coordinates 345509..345835 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Psal009_RS01785 Protein ID WP_016212365.1
Coordinates 345265..345507 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal009_RS18940 341106..341837 - 732 WP_016212311.1 hypothetical protein -
Psal009_RS01770 341958..343541 - 1584 WP_052047129.1 protein kinase -
Psal009_RS01775 343824..344552 - 729 WP_075274745.1 IS6-like element ISPsa2 family transposase -
Psal009_RS01780 344620..345060 - 441 Protein_342 tyrosine-type recombinase/integrase -
Psal009_RS01785 345265..345507 + 243 WP_016212365.1 antidote-toxin recognition MazE family protein Antitoxin
Psal009_RS01790 345509..345835 + 327 WP_036781349.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Psal009_RS01795 345951..346679 + 729 WP_054300202.1 IS6 family transposase -
Psal009_RS01800 347149..347532 + 384 WP_016212152.1 hypothetical protein -
Psal009_RS01805 347839..348216 - 378 WP_016212154.1 DDE-type integrase/transposase/recombinase -
Psal009_RS01810 348381..348713 - 333 WP_155047283.1 transposase -
Psal009_RS01820 348902..349681 - 780 WP_081377351.1 transposase -
Psal009_RS01825 349782..350039 - 258 Protein_350 DDE-type integrase/transposase/recombinase -
Psal009_RS18945 350328..350447 - 120 Protein_351 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 313707..514002 200295
- inside IScluster/Tn - - 340218..357493 17275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-104)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11971.89 Da        Isoelectric Point: 10.1733

>T123356 WP_036781349.1 NZ_CP038908:345509-345835 [Piscirickettsia salmonis]
VPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKPYNLKVGLVTGCPVTSKIKGYPFEVELPKNNSVHGAVLVNQLTTKDFR
ARGWNHADKLDKKSLERVQGLIDVMLKG

Download         Length: 327 bp

>T123356 NZ_CP038908:345509-345835 [Piscirickettsia salmonis]
GTGCCTGAACGTGGTGATATTATTTTTCTTAGTTTAGACCCTACATTAGGTAGTGAACAAAGAGGAAACCGACCCTTTTT
AGTGTTGACTTCCAAGCCCTATAACTTAAAGGTGGGACTTGTGACGGGGTGCCCGGTTACTTCAAAGATTAAAGGATATC
CTTTTGAAGTTGAGCTACCTAAAAACAATAGCGTTCACGGAGCAGTGTTGGTTAACCAACTAACAACAAAAGATTTCCGT
GCTAGGGGCTGGAATCATGCTGATAAGCTCGATAAAAAATCTCTTGAAAGAGTTCAGGGGCTAATTGATGTGATGTTGAA
AGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.09 Da        Isoelectric Point: 4.4750

>AT123356 WP_016212365.1 NZ_CP038908:345265-345507 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTIDKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEELGGERFE

Download         Length: 243 bp

>AT123356 NZ_CP038908:345265-345507 [Piscirickettsia salmonis]
ATGGATGCAGTTGTTAGAAAATGGGGGAATAGCTTGGGGTTGTTGCTACCCTTGAGCATCGCACGTGAACTTCATATCAA
TGATGGTAGTCATGTGACGATTGATAAGGTCGGGGATGAGATTCACATTAAACCTTTGACTCATACGCAGACCCTTGAAT
TATTATTATCAGAAATTACCCCTGAAAATAGTCATGATTTAGTAGATTGGGGTGAAGAATTAGGAGGGGAGCGCTTTGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References