Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 41705..42348 Replicon plasmid unnamed1
Accession NZ_CP038905
Organism Piscirickettsia salmonis strain Psal-008

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L6TI66
Locus tag Psal008_RS16465 Protein ID WP_027242931.1
Coordinates 41705..42112 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L6TI10
Locus tag Psal008_RS16470 Protein ID WP_027242932.1
Coordinates 42121..42348 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal008_RS16440 37302..38633 - 1332 WP_048876205.1 terminase large subunit -
Psal008_RS16445 38636..39118 - 483 WP_075278733.1 P27 family phage terminase small subunit -
Psal008_RS16450 39205..39588 - 384 WP_027242929.1 HNH endonuclease -
Psal008_RS16455 39784..39987 - 204 WP_017375952.1 hypothetical protein -
Psal008_RS16460 40177..41559 - 1383 WP_027242930.1 hypothetical protein -
Psal008_RS16465 41705..42112 - 408 WP_027242931.1 DUF4411 family protein Toxin
Psal008_RS16470 42121..42348 - 228 WP_027242932.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Psal008_RS16475 42481..42846 - 366 WP_026063496.1 hypothetical protein -
Psal008_RS16480 43725..44054 - 330 WP_162038692.1 HigA family addiction module antidote protein -
Psal008_RS16485 44120..44269 + 150 WP_196214251.1 hypothetical protein -
Psal008_RS16490 44407..44640 - 234 WP_017375959.1 type II toxin-antitoxin system RelE/ParE family toxin -
Psal008_RS16495 44942..45985 + 1044 WP_017375960.1 NAD(P)-dependent alcohol dehydrogenase -
Psal008_RS16500 46093..46500 + 408 WP_036817201.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..165781 165781


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(7-41)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15562.93 Da        Isoelectric Point: 7.4168

>T123353 WP_027242931.1 NZ_CP038905:c42112-41705 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLDVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVDHLELEDWAS

Download         Length: 408 bp

>T123353 NZ_CP038905:c42112-41705 [Piscirickettsia salmonis]
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAACCTCGCTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCGATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGCAGTCAAC
ACCAGCGAAAAAATCAGGAAGCAATTAATACCTTGGTGAATAAGCTCGATGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCACATGC
GCTTTCAGAAAAGGCTGTTTTAGTAACGCATAATACAAAAGAGTTTCAGCGTGTCGATCATTTAGAGCTTGAAGACTGGG
CAAGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8948.07 Da        Isoelectric Point: 4.5700

>AT123353 WP_027242932.1 NZ_CP038905:c42348-42121 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDRQDIQAQERDWF

Download         Length: 228 bp

>AT123353 NZ_CP038905:c42348-42121 [Piscirickettsia salmonis]
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCTCAAGCCGTTCGATTACCGAAAGAAATGCGCCTTGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCATATGC
CGGATGTATCGGATGATTTTATGGAGGATCGCCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TI66

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI10

References