Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 21653..22184 Replicon plasmid unnamed1
Accession NZ_CP038905
Organism Piscirickettsia salmonis strain Psal-008

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag Psal008_RS16340 Protein ID WP_027243212.1
Coordinates 21653..21940 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag Psal008_RS16345 Protein ID WP_027243211.1
Coordinates 21930..22184 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal008_RS16310 16836..17564 + 729 WP_036771359.1 IS6 family transposase -
Psal008_RS16315 17692..18669 - 978 WP_036771347.1 IS5 family transposase -
Psal008_RS16320 18751..19242 + 492 WP_069971704.1 DUF1561 family protein -
Psal008_RS16325 19350..20327 + 978 WP_036771347.1 IS5 family transposase -
Psal008_RS16330 20331..21158 + 828 WP_069971703.1 IS5 family transposase -
Psal008_RS16335 21185..21646 + 462 Protein_26 tail assembly protein -
Psal008_RS16340 21653..21940 - 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Psal008_RS16345 21930..22184 - 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Psal008_RS16350 22402..22563 - 162 WP_155046636.1 hypothetical protein -
Psal008_RS16355 22578..23555 - 978 WP_036771347.1 IS5 family transposase -
Psal008_RS16360 23574..23807 - 234 WP_062365770.1 hypothetical protein -
Psal008_RS16365 23889..24866 + 978 WP_036771347.1 IS5 family transposase -
Psal008_RS16370 24906..25250 + 345 Protein_33 DDE-type integrase/transposase/recombinase -
Psal008_RS16375 25332..26312 - 981 WP_144420849.1 hypothetical protein -
Psal008_RS16380 26544..27053 - 510 WP_027242595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..165781 165781


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T123352 WP_027243212.1 NZ_CP038905:c21940-21653 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T123352 NZ_CP038905:c21940-21653 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT123352 WP_027243211.1 NZ_CP038905:c22184-21930 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT123352 NZ_CP038905:c22184-21930 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References