Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 5446..6052 Replicon plasmid unnamed5
Accession NZ_CP038903
Organism Piscirickettsia salmonis strain Psal-006b

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B8UI87
Locus tag Psal006b_RS18440 Protein ID WP_027242955.1
Coordinates 5446..5706 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7U4WZG4
Locus tag Psal006b_RS18445 Protein ID WP_016211078.1
Coordinates 5699..6052 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal006b_RS18415 994..1977 + 984 WP_016211499.1 ParB/RepB/Spo0J family partition protein -
Psal006b_RS18420 2483..3118 + 636 WP_196214298.1 transposase -
Psal006b_RS18425 3115..4089 - 975 WP_036771330.1 IS30 family transposase -
Psal006b_RS19235 4203..4559 + 357 WP_075278739.1 transposase -
Psal006b_RS18435 4625..5215 - 591 WP_016212329.1 site-specific integrase -
Psal006b_RS18440 5446..5706 + 261 WP_027242955.1 type II toxin-antitoxin system HicA family toxin Toxin
Psal006b_RS18445 5699..6052 + 354 WP_016211078.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Psal006b_RS18450 6229..7203 + 975 WP_069971681.1 IS30 family transposase -
Psal006b_RS18455 7312..7539 + 228 Protein_9 hypothetical protein -
Psal006b_RS18460 7736..8101 + 366 WP_027242954.1 hypothetical protein -
Psal006b_RS18465 8246..8500 + 255 WP_027242953.1 type II toxin-antitoxin system HicA family toxin -
Psal006b_RS18470 8493..8840 + 348 WP_027242952.1 type II toxin-antitoxin system HicB family antitoxin -
Psal006b_RS18475 8938..9912 + 975 WP_036771330.1 IS30 family transposase -
Psal006b_RS19240 10144..10290 - 147 WP_169834793.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33267 33267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(53-103)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9695.31 Da        Isoelectric Point: 10.9468

>T123350 WP_027242955.1 NZ_CP038903:5446-5706 [Piscirickettsia salmonis]
MNNKHRKTLRDIFHNPIKASIVWADIEKLLLALGAEVIERDGSRVAVILNQVKTTFHRPHPEKTTDKGAVKSIRLFLKNA
GVDKNA

Download         Length: 261 bp

>T123350 NZ_CP038903:5446-5706 [Piscirickettsia salmonis]
ATGAATAATAAACATCGTAAGACACTAAGAGATATTTTTCATAACCCGATCAAAGCAAGCATTGTTTGGGCTGATATAGA
AAAGCTTCTTTTAGCGTTAGGGGCTGAAGTAATAGAGCGTGATGGTTCAAGGGTTGCTGTCATTTTGAATCAAGTGAAAA
CAACATTTCATAGACCGCACCCTGAAAAAACAACAGACAAGGGGGCGGTTAAGTCAATAAGGTTGTTTTTAAAAAATGCT
GGAGTAGATAAAAATGCTTAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13492.39 Da        Isoelectric Point: 5.0200

>AT123350 WP_016211078.1 NZ_CP038903:5699-6052 [Piscirickettsia salmonis]
MLKYKGYIGKVEEIHEGDEYIYGIVPNIKDVISFRGKNIKELTKDFKLAIDDYLALCDEREEEPDKPFSGRFMTRLGSDL
HEEVFLASMNDSGAKSMNDWVVSACLEKLKHDQTVKR

Download         Length: 354 bp

>AT123350 NZ_CP038903:5699-6052 [Piscirickettsia salmonis]
ATGCTTAAATACAAAGGTTATATTGGAAAAGTTGAAGAGATTCATGAAGGTGATGAATATATTTATGGGATTGTTCCAAA
TATTAAAGATGTTATTTCTTTTAGAGGTAAAAATATAAAAGAGTTAACGAAAGACTTTAAGCTGGCTATTGATGATTATT
TGGCTTTATGTGATGAGCGTGAAGAAGAACCCGATAAACCATTTTCTGGTAGATTTATGACTAGATTAGGTAGTGACTTG
CATGAAGAGGTTTTTTTAGCTTCTATGAATGATTCAGGTGCAAAATCAATGAATGATTGGGTTGTATCTGCATGCTTAGA
AAAGTTGAAGCATGATCAAACCGTTAAACGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B8UI87

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4WZG4

References